Investigating urine output and blood pressure during spinal anesthesia

Hemodynamic Determinants of Urine Output During Spinal Anesthesia

This study tests how different blood pressure levels during spinal anesthesia affect urine output in people receiving Ringer's solution.

Quick facts

• Study type: Observational
• Enrollment: 20 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu (Academic / other)
• Locations: 1 site (Bucharest)
• Trial ID: NCT06814561 on ClinicalTrials.gov

What this trial studies

This clinical trial examines how urine output is affected by mean arterial pressure (MAP) during spinal anesthesia. It aims to validate findings from animal studies in a human population by measuring hemoglobin levels, MAP, and urine output simultaneously. The study focuses on the effects of Ringer's solution on urine output, particularly how it varies with different MAP levels. By establishing a correlation among these variables, the trial seeks to provide insights into optimal fluid management during anesthesia.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 years and older who are undergoing procedures amenable to spinal anesthesia.

Not a fit: Patients with contraindications to spinal anesthesia, such as coagulopathy or severe aortic stenosis, may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve fluid management strategies during spinal anesthesia, potentially enhancing patient outcomes.

How similar studies have performed: While previous studies have explored this relationship in animal models, this approach in humans remains novel and untested.

Eligibility criteria

Inclusion Criteria:

* Written informed consent provided by patients or their legally authorized representatives.
* Adults aged 18 years and older.

Exclusion Criteria:

* Contraindications to Spinal Anesthesia:

  * Patient refusal
  * Presence of coagulopathy.
  * Current use of anticoagulant or antiplatelet medications.
  * Critical or severe aortic stenosis or other fixed cardiac output states.
  * High risk of infection at the spinal needle insertion site.
  * Elevated intracranial pressure.
  * Allergy
  * Sepsis
* Procedures Not Amenable to Spinal Anesthesia:

  * Planned concurrent procedures that cannot be performed under spinal anesthesia.

Where this trial is running

Bucharest

• "Prof CC Iliescu" Emergency Institue for Cardiovascular Diseases — Bucharest, Romania (Recruiting)

Study contacts

• Study coordinator: Cosmin Balan, PhD

Conditions Urine Output Decreased; urine output; spinal anesthesia; mean arterial pressure