Investigating urine concentration after inhaling salmeterol
Urinary Concentration After Salmeterol in Well-trained Men and Females
This study is testing how inhaling salmeterol affects urine concentration in healthy adults aged 18-40 after they exercise.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | University of Copenhagen Academic / other |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT06657547 on ClinicalTrials.gov |
What this trial studies
This project aims to examine how inhalation of salmeterol affects urine concentration in healthy individuals. The study will assess urine samples following acute physical activity under both normal and heated conditions. Participants will be physically active adults aged 18-40 with high levels of oxygen uptake. The study will involve controlled inhalation of salmeterol and subsequent urine analysis to understand the drug's effects on hydration and concentration.
Who should consider this trial
Good fit: Ideal candidates are healthy, physically active adults aged 18-40 who engage in more than 5 hours of exercise per week.
Not a fit: Patients who are smokers, have chronic illnesses, or are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the effects of salmeterol on hydration status and urinary concentration, potentially influencing treatment approaches for conditions requiring beta2-adrenergic stimulation.
How similar studies have performed: While there may be studies on salmeterol's effects, this specific investigation into urinary concentration after inhalation during physical activity appears to be novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Inclusion Criteria: * Age 18-40 * Physically active \>5 hours a week * Maximum oxygen uptake classified as high or very high Exclusion Criteria: * Active smoker currently or within the past 5 years * Regular intake of medication deemed by the responsible study physician to affect the test parameters (hormonal contraception is accepted for women) * Chronic or acute illness deemed by the responsible study physician to affect the test parameters * Deviation from the study protocol * Lean mass index \>21 kg/m² * Pregnancy * Smoker * Blood donation during the past 3 months
Where this trial is running
Copenhagen
- August Krogh Building — Copenhagen, Denmark (Recruiting)
Study contacts
- Study coordinator: Morten Hostrup, PhD
- Email: mhostrup@nexs.ku.dk
- Phone: +4535321595
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.