Investigating tick-borne encephalitis and borrelial antibodies in patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines patients in Slovenia who present with symptoms of tick-borne encephalitis and have positive borrelial antibodies in their serum. The researchers aim to determine whether these patients benefit from antibiotic treatment, given that they may not have Lyme neuroborreliosis despite the presence of borrelial antibodies. The study involves administering doxycycline and symptomatic therapy while collecting data through questionnaires. The goal is to clarify treatment protocols for patients with potential double infections.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years or older
* clinical picture compatible with tick-borne encephalitis,
* clear cerebrospinal fluid,
* cerebrospinal pleocytosis (leucocytes in cerebrospinal fluid \>5 x 106/)L,
* positive serum immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against tick-borne encephalitis virus,
* positive serum IgG antibodies against Lyme borreliae.

Exclusion Criteria:

* isolation of B.burgdorferi sensu lato from cerebrospinal fluid,
* positive intrathecal borrelial antibody production index,
* seroconversion of borrelial IgG antibodies,
* presence of erythema migrans and/or borrelial lymphocytoma in the last month,
* Bannwarth syndrome.

Where it's running

• University Medical Center Ljubljana
  Ljubljana, Slovenia Recruiting

Study contacts

• Principal investigator: Daša Stupica, MD PhD — University Medical Centre Ljubljana
• Study coordinator: Daša Stupica, MD PhD
• Email: dasa.stupica@kclj.si
• Phone: +386 31 689324

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.