Investigating the use of oxytocin during the second stage of labor

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial examines the effects of continuing oxytocin administration during the second stage of labor in nulliparous women. While oxytocin is commonly used to enhance uterine contractions during the first stage of labor, its benefits and risks during the second stage remain unclear. The study aims to determine whether continuing oxytocin can improve delivery outcomes or if it poses unnecessary risks. Participants will be randomly assigned to either continue or discontinue oxytocin after reaching complete cervical dilation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Nulliparous pregnant women \>/= 37 weeks gestation
* Singleton pregnancies
* Admission for induction of labor or spontaneous labor

Exclusion Criteria:

* Multiple gestations
* Multiparous patients
* Patients with major fetal anomalies
* Not on oxytocin at the time of complete cervical dilation
* Patients with fetal head visible at the perineum on diagnosis of complete cervical dilation
* Maternal medical condition that prohibits prolonged second stage

Where it's running

• Barnes Jewish Hospital
  St Louis, Missouri, United States Recruiting

Study contacts

• Study coordinator: Nandini Raghuraman, MD MSCI
• Email: nraghuraman@wustl.edu
• Phone: 9186917389

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using antibiotics to reduce complications in obese pregnant women during labor induction

  This study is testing if giving antibiotics to obese pregnant women during labor induction can help lower the chances of needing a cesarean delivery and reduce infections after childbirth.

  Recruiting Phase 2 University of Oklahoma · Oklahoma City, Oklahoma · NCT06488781

• Tracking walking movements during labor with inertial sensors

  This study is testing how walking during the first stage of labor affects the experience and outcomes for women who are at least 38 weeks pregnant and using low-dose epidurals.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06471790

• Using ultrasound during labor to reduce infections

  This study is testing if using ultrasound to check on labor can help reduce infections compared to traditional methods that involve more invasive exams.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT06261710

• Early ultrasound and side-lying position with a peanut ball for babies facing up or sideways during labor

  This trial tests whether asking people in active labor whose babies are occiput posterior or occiput transverse to lie on their side with a peanut ball helps them have a spontaneous vaginal delivery.

  Recruiting Women and Infants Hospital of Rhode Island · Providence, Rhode Island · NCT05881629

• Testing a new guide for monitoring labor and childbirth in Norway

  This study is testing a new guide for monitoring labor and childbirth to see if it can improve care and reduce unnecessary interventions for mothers and babies in Norway.

  Recruiting at 9 sites Ostfold Hospital Trust · Nordbyhagen, Akershus and 9 other locations · NCT05791630

• Safe Induction of Labor

  This study tests whether using Buscopan, sodium bicarbonate, or a placebo can make labor induction safer and more effective for first-time pregnant women who are at least 37 weeks along.

  Recruiting at 5 sites Phase 3 Oslo University Hospital · Lørenskog and 4 other locations · NCT05719467

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.