Investigating the timing of intubation in COVID-19 patients with respiratory failure
Official title: Effects of Early vs. Delayed Invasive Mechanical Ventilation: A Target Trial Emulation
Run by Erasmus Medical Center · NCT06757166 · Data updated 2026-11-12
This study is trying to see if intubating COVID-19 patients earlier or later can lead to better health outcomes and lower risks of lung injury.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50000 (estimated) |
| Sponsor | Erasmus Medical Center Academic / other |
| Locations | 1 site (Rotterdam, South Holland) |
| Status | Recruiting |
| Started | January 1, 2018 |
| Main results expected | January 2025 |
| Study ends | January 2025 |
| Registry record updated | January 3, 2025 |
| Trial ID | NCT06757166 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include hospitalized adults aged 18 and older experiencing hypoxemic respiratory failure with an S/F ratio less than 250 who have not yet been intubated.
✕Probably not a fit
Patients with a do-not-intubate order or those who already have a tracheostomy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the impact of early versus late endotracheal intubation on clinical outcomes in patients with SARS-CoV-2-related hypoxemic respiratory failure. It focuses on determining whether delaying intubation after non-invasive respiratory support increases the risk of lung injury and affects mortality rates. The study will analyze various thresholds for initiating intubation based on the patient's oxygenation and respiratory rate to identify optimal timing for intervention. By comparing different treatment regimes, the research seeks to improve patient outcomes related to invasive mechanical ventilation.
Why it matters
Potential benefit: If successful, this study could lead to improved survival rates and reduced duration of invasive ventilation for COVID-19 patients.
How similar studies have gone: While the approach of investigating intubation timing is critical, similar studies have shown mixed results, indicating that this area remains an important and novel field of inquiry.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hospitalized (inpatient or ICU) * 18 years or older * Hypoxemic respiratory failure: S/F\<250 * Not yet intubated Exclusion Criteria: * Do not intubate order * Presence of tracheostomy
Where it's running
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Erasmus Medical Centre
Rotterdam, South Holland, Netherlands Recruiting
Study contacts
- Study coordinator: Carmen A.T. Reep, MSc
- Email: c.reep@erasmusmc.nl
- Phone: +31628164764
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.