Investigating the timing of intubation in COVID-19 patients with respiratory failure
Effects of Early vs. Delayed Invasive Mechanical Ventilation: A Target Trial Emulation
This study is trying to see if intubating COVID-19 patients earlier or later can lead to better health outcomes and lower risks of lung injury.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Erasmus Medical Center Academic / other |
| Locations | 1 site (Rotterdam, South Holland) |
| Trial ID | NCT06757166 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the impact of early versus late endotracheal intubation on clinical outcomes in patients with SARS-CoV-2-related hypoxemic respiratory failure. It focuses on determining whether delaying intubation after non-invasive respiratory support increases the risk of lung injury and affects mortality rates. The study will analyze various thresholds for initiating intubation based on the patient's oxygenation and respiratory rate to identify optimal timing for intervention. By comparing different treatment regimes, the research seeks to improve patient outcomes related to invasive mechanical ventilation.
Who should consider this trial
Good fit: Ideal candidates include hospitalized adults aged 18 and older experiencing hypoxemic respiratory failure with an S/F ratio less than 250 who have not yet been intubated.
Not a fit: Patients with a do-not-intubate order or those who already have a tracheostomy will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved survival rates and reduced duration of invasive ventilation for COVID-19 patients.
How similar studies have performed: While the approach of investigating intubation timing is critical, similar studies have shown mixed results, indicating that this area remains an important and novel field of inquiry.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hospitalized (inpatient or ICU) * 18 years or older * Hypoxemic respiratory failure: S/F\<250 * Not yet intubated Exclusion Criteria: * Do not intubate order * Presence of tracheostomy
Where this trial is running
Rotterdam, South Holland
- Erasmus Medical Centre — Rotterdam, South Holland, Netherlands (Recruiting)
Study contacts
- Study coordinator: Carmen A.T. Reep, MSc
- Email: c.reep@erasmusmc.nl
- Phone: +31628164764
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.