Investigating the spread of antibiotic-resistant bacteria in hospitals
Transmission of ESBL-producing Enterobacteriaceae and Their Mobile Genetic Elements-identification of Sources by Whole Genome Sequencing
This study is trying to find out how antibiotic-resistant bacteria spread in hospitals by looking at samples from patients over 16 years to see if the hospital or outside sources are more responsible for infections.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 1 Year and up |
| Sex | All |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 1 site (Basel) |
| Trial ID | NCT03465683 on ClinicalTrials.gov |
What this trial studies
This research project aims to explore the transmission of ESBL-producing Enterobacteriaceae, a type of antibiotic-resistant bacteria, in the Basel urban region. By utilizing whole genome sequencing, the study will analyze bacterial strains and mobile genetic elements to identify transmission chains and sources of hospital-acquired infections. The findings will help determine whether hospital environments or external sources contribute more significantly to the spread of these infections. The study will include samples collected from patients at the University Hospital Basel over a 16-year period.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged over 1 year who have been confirmed to carry ESBL-producing Enterobacteriaceae.
Not a fit: Patients who do not meet the inclusion criteria or do not have proven ESBL-PE carriage will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing and controlling hospital-acquired infections caused by antibiotic-resistant bacteria.
How similar studies have performed: Other studies have shown success in understanding the transmission dynamics of antibiotic-resistant bacteria using genomic sequencing, indicating that this approach is both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * aged above 1 year * proven ESBL-PE carriage from any specimens obtained by routine clinical practice out and inpatients from University Hospital Basle from January 1st until December 31st 2019 Exclusion Criteria: * not meeting inclusion criteria
Where this trial is running
Basel
- University Hospital Switzerland, Division of Infecteous Disease and Hospital Epidemiology — Basel, Switzerland (Recruiting)
Study contacts
- Principal investigator: Sarah Tschudin-Sutter, PD MD — Division of Infectious Disease and Hopital Epidemiology, University Hospital Basle
- Study coordinator: Sarah Tschudin-Sutter, PD MD
- Email: sarah.tschudin@usb.ch
- Phone: ++41 61 328
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.