Clinical trial Recruiting at 1 site Observational Ages 1 Year and up

Investigating the spread of antibiotic-resistant bacteria in hospitals

Official title: Transmission of ESBL-producing Enterobacteriaceae and Their Mobile Genetic Elements-identification of Sources by Whole Genome Sequencing

Run by University Hospital, Basel, Switzerland · NCT03465683 · Data updated 2026-11-12

This study is trying to find out how antibiotic-resistant bacteria spread in hospitals by looking at samples from patients over 16 years to see if the hospital or outside sources are more responsible for infections.

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Quick facts

Study typeObservational
Ages1 Year and up
SexAll
Enrollment2000 (estimated)
SponsorUniversity Hospital, Basel, Switzerland
Academic / other
Locations1 site (Basel)
StatusRecruiting
StartedMarch 1, 2017
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedJune 8, 2026
Trial IDNCT03465683 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals aged over 1 year who have been confirmed to carry ESBL-producing Enterobacteriaceae.

Probably not a fit

Patients who do not meet the inclusion criteria or do not have proven ESBL-PE carriage will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research project aims to explore the transmission of ESBL-producing Enterobacteriaceae, a type of antibiotic-resistant bacteria, in the Basel urban region. By utilizing whole genome sequencing, the study will analyze bacterial strains and mobile genetic elements to identify transmission chains and sources of hospital-acquired infections. The findings will help determine whether hospital environments or external sources contribute more significantly to the spread of these infections. The study will include samples collected from patients at the University Hospital Basel over a 16-year period.

Why it matters

Potential benefit: If successful, this study could lead to improved strategies for preventing and controlling hospital-acquired infections caused by antibiotic-resistant bacteria.

How similar studies have gone: Other studies have shown success in understanding the transmission dynamics of antibiotic-resistant bacteria using genomic sequencing, indicating that this approach is both relevant and potentially impactful.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* aged above 1 year
* proven ESBL-PE carriage from any specimens obtained by routine clinical practice out and inpatients from University Hospital Basle from January 1st until December 31st 2019

Exclusion Criteria:

* not meeting inclusion criteria

Where it's running

  • University Hospital Switzerland, Division of Infecteous Disease and Hospital Epidemiology
    Basel, Switzerland
    Recruiting

Study contacts

  • Principal investigator: Sarah Tschudin-Sutter, PD MD — Division of Infectious Disease and Hopital Epidemiology, University Hospital Basle
  • Study coordinator: Sarah Tschudin-Sutter, PD MD
  • Email: sarah.tschudin@usb.ch
  • Phone: ++41 61 328

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.