Investigating the role of uromodulin and sodium intake on blood pressure in chronic kidney disease patients
The Effect of Dietary Sodium Intake on Ambulatory Blood Pressure Levels According to Urinary Uromodulin Levels in Patients With Chronic Kidney Disease
This study is trying to see how levels of a substance called uromodulin and how much salt people eat affect blood pressure in adults with chronic kidney disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 130 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Aristotle University Of Thessaloniki Academic / other |
| Locations | 1 site (Thessaloníki, Central Macedonia) |
| Trial ID | NCT06363097 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between urinary uromodulin levels, dietary sodium intake, and ambulatory blood pressure in patients with chronic kidney disease (CKD). It involves a cross-sectional evaluation of adult CKD patients who meet specific inclusion and exclusion criteria. Participants will undergo a series of assessments, including demographic data collection, physical examinations, and blood sampling, while adhering to pre-study guidelines regarding food and medication intake. The study is conducted at the 1st Department of Nephrology at Hippokration Hospital in Thessaloniki, Greece.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 years and older diagnosed with chronic kidney disease according to KDIGO criteria.
Not a fit: Patients who have undergone kidney transplantation, are on dialysis, or have chronic arrhythmias may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of sodium sensitivity in CKD patients, potentially leading to improved management of hypertension in this population.
How similar studies have performed: While the specific approach of this study may be novel, previous studies have indicated a significant role of uromodulin in kidney physiology and hypertension, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥18 years 2. CKD defined based on the KDIGO criteria 3. Provision of informed written consent Exclusion Criteria: 1. Kidney transplantation or end-stage kidney disease (ESKD) under hemodialysis or peritoneal dialysis 2. Chronic atrial fibrillation or other diagnosed arrhythmia intervening with a proper 24-hour ABPM recording 3. Inability to reliably complete the study questionnaires 4. Pregnancy
Where this trial is running
Thessaloníki, Central Macedonia
- 1st Department of Nephrology — Thessaloníki, Central Macedonia, Greece (Recruiting)
Study contacts
- Study coordinator: Artemios G. Karagiannidis, MD, MSc
- Email: artemiskaragiannidis@gmail.com
- Phone: +30 6970362392
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.