Investigating the role of senescent cells in uterine fibroids
Role of Senescent Cells in Uterine Fibroid Pathogenesis
This study is trying to see how certain aging cells affect the growth of uterine fibroids to help find better treatments for women dealing with these tumors.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | Female |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT06135870 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates how senescent cells contribute to the development of uterine fibroids, which are common tumors in the uterus. Researchers are utilizing advanced computational methods to explore the interactions between senescent and immune cells within fibroid tissues. The goal is to understand the communication networks that lead to fibrosis, potentially paving the way for new treatment options for women suffering from uterine fibroids.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18 to 55 who have suspected uterine fibroids.
Not a fit: Patients who are pregnant or have uterine cancer will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to innovative treatments for uterine fibroids, improving the quality of life for affected women.
How similar studies have performed: While the role of senescent cells in other conditions has been explored, this specific focus on uterine fibroids is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects must be women above the age of ≥18 - ≤55 years. * Women with suspected uterine fibroids. * Subject must be or have been sexually active or have had a previous vaginal exam that used a speculum. * Subject must be able to understand, read and speak English or Spanish and subsequently, be able to understand what she is consenting to in terms of procedures and use/disclosure of protected health information. Exclusion Criteria: * Unwilling to sign the consent form or complete questionnaire. * Pregnancy. * Cancer of the uterus
Where this trial is running
Baltimore, Maryland
- Johns Hopkins Hospital — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: James Segars, MD — Johns Hopkins University
- Study coordinator: James Segars, MD
- Email: jsegars2@jhmi.edu
- Phone: 410-614-2000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.