Investigating the role of micronerves in Dupuytren's disease and their impact on recurrence
Observational Study on Small Nerve Bundles in Dupuytren Disease and the Impact of Its Dissection on Recurrence.
This study looks at whether tiny nerve bundles in the hand affect how often Dupuytren's disease comes back after surgery in people with this condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven, Vlaams-Brabant) |
| Trial ID | NCT06142929 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on Dupuytren's disease, a condition that causes finger contractures due to fibrosis in the palm. It aims to explore the presence of small nerve bundles, known as micronerves, and their potential role in the recurrence of the disease after surgical intervention. By comparing two groups of patients—those with primary Dupuytren's disease and those with recurrent cases—the study will document the presence of these micronerves and any associated neuromas. Additionally, the study will evaluate the levels of nerve growth factor to understand its relationship with neuro-induced fibrosis.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older diagnosed with either primary or recurrent Dupuytren's disease who are eligible for microfasciectomy.
Not a fit: Patients under 18 years old, those with cognitive impairments, severe rheumatic diseases, or neurological disorders affecting finger movement may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical techniques that reduce the recurrence of Dupuytren's disease.
How similar studies have performed: While the investigation of micronerves in Dupuytren's disease is a novel approach, similar studies have shown that understanding nerve involvement can impact treatment outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: Participants eligible for inclusion in this study must meet all of the following criteria: 1. The participant or his/her legally authorized representative voluntary signed the informed consent prior to the first assessment 2. Participants are ≥ 18 years and diagnosed with primary/recurrent Dupuytren disease 3. Included patients are eligible for microfasciectomy Exclusion criteria: Participants eligible for this study must not meet any of the following criteria: 1. Patients \< 18 years 2. Patient included in an interventional trial with an investigational medicinal product 3. Patients with cognitive impairments, severe rheumatic disease and neurological disorders leading to flexion deformities of the fingers
Where this trial is running
Leuven, Vlaams-Brabant
- Universitaire Ziekenhuizen KU Leuven — Leuven, Vlaams-Brabant, Belgium (Recruiting)
Study contacts
- Principal investigator: Ilse Degreef, Prof. Dr. — Universitaire Ziekenhuizen KU Leuven
- Study coordinator: Ilse Degreef, Prof. Dr.
- Email: ilse.degreef@uzleuven.be
- Phone: +32 16 33 88 43
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.