Investigating the role of micronerves in Dupuytren's disease and their impact on recurrence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on Dupuytren's disease, a condition that causes finger contractures due to fibrosis in the palm. It aims to explore the presence of small nerve bundles, known as micronerves, and their potential role in the recurrence of the disease after surgical intervention. By comparing two groups of patients—those with primary Dupuytren's disease and those with recurrent cases—the study will document the presence of these micronerves and any associated neuromas. Additionally, the study will evaluate the levels of nerve growth factor to understand its relationship with neuro-induced fibrosis.

Why it matters

Who can join: the full rules

Inclusion criteria:

Participants eligible for inclusion in this study must meet all of the following criteria:

1. The participant or his/her legally authorized representative voluntary signed the informed consent prior to the first assessment
2. Participants are ≥ 18 years and diagnosed with primary/recurrent Dupuytren disease
3. Included patients are eligible for microfasciectomy

Exclusion criteria:

Participants eligible for this study must not meet any of the following criteria:

1. Patients \< 18 years
2. Patient included in an interventional trial with an investigational medicinal product
3. Patients with cognitive impairments, severe rheumatic disease and neurological disorders leading to flexion deformities of the fingers

Where it's running

• Universitaire Ziekenhuizen KU Leuven
  Leuven, Vlaams-Brabant, Belgium Recruiting

Study contacts

• Principal investigator: Ilse Degreef, Prof. Dr. — Universitaire Ziekenhuizen KU Leuven
• Study coordinator: Ilse Degreef, Prof. Dr.
• Email: ilse.degreef@uzleuven.be
• Phone: +32 16 33 88 43

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Treatment for early Dupuytren's disease using vitamin E cream

  This study is testing if using vitamin E cream can help people with early Dupuytren's disease stop their fingers from getting worse.

  Recruiting Phase 2 Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06321991

• Treatment options for Dupuytren's contracture

  This study is testing whether adding a corticosteroid injection to a needle treatment helps people with Dupuytren's contracture move their fingers better.

  Recruiting Phase 4 Regionshospitalet Silkeborg · Silkeborg · NCT05440240

• Evaluating night splinting after needle fasciotomy for Dupuytren's contracture

  This study is testing if wearing a night splint after a needle procedure for Dupuytren's contracture can help prevent the condition from coming back compared to just physical therapy alone.

  Recruiting at 3 sites Uppsala University · Falun, Dalarna County and 2 other locations · NCT05300893

• Surgery with fat grafting for Dupuytren's disease recurrence

  This study is testing whether adding fat grafting to standard surgery for Dupuytren's disease can help prevent the condition from coming back.

  Recruiting at 2 sites Elsan · Pessac and 1 other locations · NCT05067764

• Evaluating post-surgery radiation treatment for Dupuytren's disease

  This study is testing whether adding radiation treatment after surgery for Dupuytren's disease can help improve hand function and reduce symptoms for patients.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04122313

• CNT201 collagenase injection for Dupuytren’s: safety and signals of efficacy in adults

  A randomized, placebo-controlled study will test CNT201 injections to see if they are safe and help improve finger contractures in adults with Dupuytren’s disease.

  Recruiting Phase 1/2 Connext · Kippa-Ring, Queensland · NCT07640425

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.