Investigating the role of lymphatic organs and the heart after a heart attack

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study explores the adaptive immune response's role in healing and remodeling the heart following an acute myocardial infarction. It aims to identify blood-derived biomarkers that can predict the immune response to cardiac injury through multimodal imaging techniques. The research focuses on the relationship between lymphocyte activity in lymph nodes and myocardial healing, particularly using CXCR4 PET-based imaging to assess immune response non-invasively. By understanding these dynamics, the study seeks to improve therapeutic interventions for patients recovering from heart attacks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients with acute myocardial infarction (STEMI) who were treated with immediate catheterization
* stable clinical course
* male/female, above 18 years old

Exclusion Criteria:

* hemodynamic instablity \> 48 h after immediate catherization
* known CAD
* known structural heart disease
* multi vessel disease
* NSTEMI
* sarcoidosis
* immunosuppressive therapy
* acute inflammatory disease
* no consent obtainable
* contraindiations for CMR
* impaired renal function
* active cardiac implants, ferromagnetic implants
* pregnancy, breast-feeding

Where it's running

• Klinikum Würzburg Mitte, Medizinische Klinik
  Würzburg, Germany Recruiting
• University Hospital Wuerzburg
  Würzburg, Germany Recruiting

Study contacts

• Principal investigator: Theresa Reiter, MD — Wuerzburg University Hospital
• Study coordinator: Theresa Reiter, MD
• Email: reiter_t@ukw.de
• Phone: +4993120139944

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.