Investigating the Role of Inflammasome in Platelet Activation During Sepsis
Official title: Study and Role of Inflammasome in Platelet Activation During Bacterial And/or Viral Sepsis
Run by Centre Hospitalier Universitaire de la Guadeloupe · NCT06657781 · Data updated 2026-11-12
This study is trying to see how a specific part of the immune system affects platelets in people with different levels of sepsis caused by infections.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 171 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de la Guadeloupe Academic / other |
| Locations | 1 site (Les Abymes, Guadeloupe) |
| Status | Recruiting |
| Started | November 30, 2022 |
| Main results expected | November 2026 |
| Study ends | November 2026 |
| Registry record updated | October 24, 2024 |
| Trial ID | NCT06657781 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years with confirmed bacterial or viral sepsis.
✕Probably not a fit
Patients under 18 years or those who refuse participation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to estimate and compare the activation rate of the NLRP3 inflammasome in platelets among patients suffering from bacterial and/or viral sepsis, categorized by severity levels using the Sequential Organ Failure Assessment (SOFA) score. It focuses on understanding how platelets contribute to the inflammatory response and cytokine storm associated with sepsis. The study will involve five groups of patients, including those with confirmed bacterial infections and a control group of non-infected patients. By analyzing the levels of pro-inflammatory cytokines and the activation of the inflammasome, the research seeks to clarify the role of platelets in sepsis-related complications.
Why it matters
Potential benefit: If successful, this study could enhance understanding of sepsis mechanisms and lead to improved treatment strategies for patients experiencing severe infections.
How similar studies have gone: While the role of inflammasomes in sepsis is being explored, this specific approach focusing on platelet activation is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * For all groups: patients older than 18 years at inclusion and acceptation of participation by the patient, his relative or his legal representative (depending on the situation) * For groups 1, 2, 3 and 5: Patient with a confirmed sepsis (microbiological confirmation) * For group 4 : Patient non infected Exclusion Criteria: * Refusal of participation by the patient, his relative or his legal representative (depending on the situation) * Patients subject to a safeguard measure of justice * Patients younger than 18 years at inclusion
Where it's running
-
Centre Hospitalier Universitaire de la Guadeloup
Les Abymes, Guadeloupe, Guadeloupe Recruiting
Study contacts
- Principal investigator: Frédéric MARTINO, Doctor — chu de pointe à pitre
- Study coordinator: Frédéric MARTINO, Doctor
- Email: frederic.martino@chu-guadeloupe.fr
- Phone: +590 590 89 10 10
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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GRADY: a computer tool to detect early sepsis and gram-negative bloodstream infection in ICU patients
The GRADY tool will be tested to see if routine vital signs and lab results can detect early sepsis and gram-negative bloodstream infection in adult ICU patients.
-
New treatment options for infections caused by drug-resistant bacteria
This study is testing different combinations of antibiotics to see if they can help ICU patients with tough infections caused by drug-resistant bacteria.
-
Molecular culture for diagnosing sepsis in children
This study is testing a faster way to diagnose sepsis in newborns and children by using a new blood test to see if it can identify infections more quickly than the usual method.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.