Investigating the role of immune cell processes in coronary artery disease
Official title: Role of Mitophagy in Myeloid Cells During Coronary Atherosclerosis.
Run by Centre Hospitalier Universitaire Dijon · NCT05708547 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is trying to see if changes in immune cells can help us understand coronary artery disease better by comparing patients with and without atherosclerosis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Trial ID | NCT05708547 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients scheduled for cardiac bypass or valve surgery who meet specific health criteria related to coronary and peripheral artery conditions.
✕Probably not a fit
Patients with conditions that alter mitochondrial function or those under legal protection measures will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the role of mitophagy in myeloid cells during coronary atherosclerosis by comparing patients with atherosclerosis to those without. It will involve collecting blood and myocardial tissue samples from 50 patients scheduled for cardiac surgeries, divided into two groups based on their coronary health. The study seeks to identify a non-invasive marker for immune cell reprogramming associated with atherosclerosis, which could enhance understanding of the disease's progression. Participation will last for one month, and the study will be conducted at the Dijon Bourgogne University Hospital.
Why it matters
Potential benefit: If successful, this study could lead to the identification of new biomarkers for coronary atherosclerosis, improving early detection and treatment strategies.
How similar studies have gone: While the specific approach of this study is novel, similar studies have shown promise in understanding immune cell roles in atherosclerosis.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: - Person who provides oral consent Group 1: - Patient scheduled for cardiac bypass surgery (isolated procedure) with extracorporeal circulation Group 2: * Patient scheduled for valve ou ascending aorta surgery with extracorporeal circulation * No coronary lesion * No peripheral arterial disease (limbs, carotids, aortic aneurysm) Exclusion Criteria: * Person not affiliated with national health care system * Medication that alters mitochondrial function (Chloroquine, hydroxychloroquine, rapamycin, carbamazepine, resveratrol, sildenafil) * Person under a legal protection measure (curatorship, guardianship, tutorship) * Pregnant, parturient or breastfeeding women * Major unable to express consent * Minor
Where it's running
-
Chu Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Pierre-Alain BAHR
- Email: pierre-alain.bahr@chu-dijon.fr
- Phone: 03 80 29 30 21
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Prevalence of Myocardial Bridging and its relation to Coronary Plaques on MDCT
This study tests how common myocardial bridging is and whether it relates to coronary plaque in patients undergoing coronary CT angiography.
-
Assessing heart disease risk in former NFL players
This study looks at heart disease risk in retired NFL players by checking their heart health with special scans to see how their past as professional athletes affects them.
-
Switching from cigarettes to heated tobacco products and its effects on heart disease
This study is testing whether switching from regular cigarettes to heated tobacco products can help people with heart disease reduce the damage to their arteries.
-
New MRI technique for evaluating coronary atherosclerosis
This study is testing a new MRI method to see if it can better and faster help doctors check for heart artery problems in healthy people and those who might have heart disease.
-
Registry for patients with non-obstructive coronary artery disease
This study looks at people with non-obstructive coronary artery disease to see how common chest pain is and if personalized treatments can improve their symptoms and overall health over five years.
-
Understanding Myocardial Ischemia Without Blocked Arteries
This study is trying to understand heart problems caused by non-blocked arteries in patients with chest pain to see how well different treatments work over five years.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.