Investigating the Role of Gut Microbiota in Anorexia Nervosa
Official title: Discovering New Insights Into Anorexia Nervosa: Influence of MicrObial DysbiosiS (DIAMOnDS)
Run by Nantes University Hospital · NCT06043154 · Data updated 2026-11-12
This study is testing how the bacteria in the gut might affect weight gain fears and fat distribution in people with severe anorexia nervosa during their recovery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 15 Years and up |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 1 site (Nantes) |
| Status | Recruiting |
| Started | February 22, 2024 |
| Main results expected | September 30, 2028 |
| Study ends | September 30, 2028 |
| Registry record updated | November 14, 2025 |
| Trial ID | NCT06043154 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women over 15 years old with a diagnosis of severe to extreme anorexia nervosa who are admitted for refeeding.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or have recently gained weight may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study explores the relationship between gut microbiota and the central adiposity phenotype in patients with anorexia nervosa during refeeding. It aims to understand how the composition and products of gut microbiota may influence patients' fears of weight gain and the distribution of fat in the body. Patients with severe to extreme anorexia nervosa will undergo clinical examinations and stool analysis to identify potential biomarkers linked to their condition. The findings could provide insights into the mechanisms affecting treatment resistance and relapse in anorexia nervosa.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for anorexia nervosa by addressing underlying biological factors related to gut health.
How similar studies have gone: While the investigation of gut microbiota in anorexia nervosa is a relatively novel approach, similar studies in other conditions have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women * Over 15 years old and 3 months. * Admitted in the specialized department for eating disorders of CHU Nantes for refeeding. * With a diagnosis of anorexia nervosa at admission (restrictive or Binge-Eating-Purging type). * Body Mass Index at admission below 16 kilogram per square meter. * Written informed consent for patients over 18 years old/ oral informed consent from both the patient and a legal representative for patients under 18 years old. * Affiliated with French social security system or beneficiary from such system. Exclusion Criteria: * Pregnant and breastfeeding women. * Who received a treatment with antibiotic/antifungal (other than local application) in the last three months. * Who had a weight gain in the last month (5% or more of the patient's weight at admission). * Under trusteeship or guardianship. * Not fluent in French * Who participate in another interventional study involving medication. * Patients for whom stool collection or body mass composition analysis (with Dual-energy X-ray absorptiometry) couldn't be done during the first week of hospitalisation.
Where it's running
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Nantes University Hospital
Nantes, France Recruiting
Study contacts
- Study coordinator: Marie GRALL-BRONNEC, Professor
- Email: marie.bronnec@chu-nantes.fr
- Phone: +33 2 40 84 76 20
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.