Investigating the role of FGF23 in pregnancy-related hypertension
Expression of Endocrine Fibroblast Growth Factor 23 and Hypertensive Disorder Complicating Pregnancy
This study is trying to see if the levels of a protein called FGF23 are linked to high blood pressure during pregnancy by looking at blood samples from pregnant women with and without hypertension.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | First Affiliated Hospital, Sun Yat-Sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT03821922 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between fibroblast growth factor 23 (FGF23) levels and hypertensive disorders during pregnancy. It involves enrolling 100 pregnant women diagnosed with hypertension and 200 control women with normal pregnancies, matched for maternal and gestational age. Blood samples will be collected during each trimester to measure serum FGF23 levels and analyze their correlation with various health parameters. The study utilizes statistical methods to assess differences and relationships among the collected data.
Who should consider this trial
Good fit: Ideal candidates for this study are pregnant women with singleton pregnancies who are receiving regular antenatal care.
Not a fit: Patients with multiple pregnancies or those with pre-existing conditions such as hypertension or thyroid diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the mechanisms behind pregnancy-induced hypertension, potentially leading to better management and outcomes for affected mothers and infants.
How similar studies have performed: While the specific role of FGF23 in pregnancy-induced hypertension is not extensively studied, related research on vitamin D and endothelial function suggests potential avenues for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women with singleton pregnancy; * Regular antenatal examination from the first trimester; * Give birth in the university hospital (The 1st affiliated hospital of Sun Yat-sen University) Exclusion Criteria: * Younger than 18 years old; * Older than 40 years old; * Multiple pregnancy; * Complicated with other diseases such as hypertension, eclampsia, thyroid diseases, etc.
Where this trial is running
Guangzhou, Guangdong
- Obstetrics and Gynechology Department of the 1st affiliated hospital of Sun Yat-sen University — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Study coordinator: Dongyu Wang, M.D,PhD
- Email: dongyugd@aliyun.com
- Phone: 86-020-87755766
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.