Investigating the prevalence of carotid web in families
Family Screening for Internal Carotid Diaphragm Dysplasia (Carotid WEB): a Doppler Ultrasound Study
This study is trying to find out how common carotid web is among family members of patients who have it, to see if there are any genetic links to this condition that can increase stroke risk.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University Hospital, Toulouse Academic / other |
| Locations | 1 site (Toulouse) |
| Trial ID | NCT06336083 on ClinicalTrials.gov |
What this trial studies
This study aims to determine the prevalence of carotid web among first-degree relatives of patients diagnosed with carotid web using carotid duplex doppler ultrasound. Carotid web is a rare condition that poses a high risk of stroke, particularly in young adults, and its familial patterns have not been previously established. By examining relatives of affected individuals, the researchers hope to uncover potential genetic factors associated with this condition. The study will include 30 index patients and 60 relatives, all under the age of 65, at Toulouse University Hospital in France.
Who should consider this trial
Good fit: Ideal candidates include first-degree relatives of patients diagnosed with carotid web who are younger than 65 years old.
Not a fit: Patients who are not first-degree relatives of individuals with carotid web or those over the age of 65 may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could identify genetic predispositions to carotid web, leading to earlier detection and prevention strategies for at-risk individuals.
How similar studies have performed: While the familial aspects of carotid web have not been extensively studied, similar approaches in investigating genetic factors in other vascular conditions have shown promise.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Carotid Web index patients: * Patients with carotid web confirmed by CT angiogram (CTA) of cervical arteries or digital substraction angiogram (DSA). * At least one first degree relative aged younger than 65 years old. Relatives patients : \- First degree relatives of patient with diagnosed carotid web. Exclusion Criteria: * Persons placed under judicial protection or under another protection status * Pregnant or breastfeeding woman.
Where this trial is running
Toulouse
- CHU de Toulouse, Purpan — Toulouse, France (Recruiting)
Study contacts
- Principal investigator: Claire VILLEPINTE, MD — University Hospital, Toulouse
- Study coordinator: Louis FONTAINE, MD
- Email: fontaine.l@chu-toulouse.fr
- Phone: 05 61 77 93 67
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.