Investigating the nasal environment in obese and lean individuals
Role of the Nasal Microbiota in Obesity - the microNASA Study
This study looks at how the nasal environment differs between people who are obese and those who are lean to see what role it might play in weight issues.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 1 site (Basel) |
| Trial ID | NCT06153654 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the differences in the nasal environment between individuals with obesity and those who are lean. It will include 150 participants, divided into three groups: obese individuals, lean individuals, and obese individuals scheduled for bariatric surgery. The study will assess factors such as olfactory function and the nasal microbiome to understand their roles in adiposity. Participants will be aged 18-55 and must meet specific BMI criteria to qualify.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-55 with either obesity (BMI > 30 kg/m2) or who are lean (BMI 18-25 kg/m2).
Not a fit: Patients with chronic or acute sinusitis, recent nasal surgery, or severe chronic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the relationship between nasal health and obesity, potentially leading to new treatment strategies.
How similar studies have performed: While the specific focus on the nasal environment in relation to obesity is novel, related studies on the microbiome and obesity have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: N=50 adult male and female patients with obesity will be included in this study. Inclusion criteria: Inclusion criteria: * Age 18-55 years * Written informed consent * BMI \> 30 kg/m2 N=50 adult lean patients age- and sex-matched to the group of obese patients will be included in this study. Inclusion criteria: * Age 18-55 years * Written informed consent * BMI 18-25 kg/m2 N=50 adult male and female patients with obesity with scheduled bariatric will be included in this study Inclusion criteria: * Age 18-55 years * Written informed consent * BMI \> 35 kg/m2 Exclusion Criteria: * Smoking * Chronic or acute sinusitis * Surgical intervention of the nasal cavity or the paranasal sinus * Use of antibiotics within the last 31 days18 * Current illicit drug abuse including daily marijuana or CBD consumption (≤ 24 g of alcohol per day allowed) * Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease) * Use of any kind of decongestant more than twice a week * Use of cortisone-containing nasal spray within the last 3 months * Acute allergic rhinitis * History of neurodegenerative diseases * History of severe head trauma * Severe renal impairment (e.g. estimated glomerular filtration rate \<30 ml/min/m2)
Where this trial is running
Basel
- University Hospital Basel — Basel, Switzerland (Recruiting)
Study contacts
- Principal investigator: Katharina Timper, Prof. Dr. med. — University Hospital, Basel, Switzerland
- Study coordinator: Katharina Timper, Prof. Dr. med.
- Email: katharina.timper@usb.ch
- Phone: +41 61 328 57 42
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.