Investigating the microbiome and HPV status in couples facing fertility issues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between the microbiome and human papilloma virus (HPV) status in couples experiencing subfertility. The study will involve 150 couples over 24 months, collecting samples from various microbiomes and conducting HPV analysis. Additionally, a randomized placebo-controlled pilot study will assess the effects of probiotics on sperm quality in 30 subfertile men with asthenozoospermia. The outcomes will include time to pregnancy, pregnancy rates, and live birth rates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Couples (Males and females) with subfertility, primary or secondary infertility, or recurrent pregnancy loss.

Exclusion Criteria:

* unable to consent
* diseases or conditions that might impact investigation
* intake of probiotics, antibiotics within last 3 months
* intake of nutritional supplements
* chemo therapy or radiation therapy
* excess alcohol intake
* smoking

Where it's running

• Medical University of Graz
  Graz, Styria, Austria Recruiting

Study contacts

• Principal investigator: Martina Kollmann, PD Dr. — Medical University of Graz
• Study coordinator: Sarah Feigl, Dr.
• Email: s.feigl@medunigraz.at
• Phone: 004331638580831

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating a new method for sperm capacitation

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• New non-invasive method for selecting embryos in IVF

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• The FLORA project: looking for endometrium microbes linked to chronic endometritis and pregnancy success

  This study tests the relationship between the endometrial microbiome and chronic endometritis in women undergoing IVF/ICSI.

  Recruiting Universitair Ziekenhuis Brussel · Brussels · NCT05337072

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.