Investigating the long-term effects of COVID-19 on multiple organs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The C-MORE study is a prospective observational study that aims to characterize the prevalence of multi-organ injury among COVID-19 survivors after hospital discharge. It will utilize advanced magnetic resonance imaging (MRI) technology to assess the lungs, heart, brain, liver, and kidneys of 616 patients at 3, 6, and 12 months following the onset of COVID-19 symptoms. Additionally, the study will evaluate the impact of these injuries on quality of life, exercise tolerance, and mental health. By examining the relationship between persistent multi-organ damage and various factors, the study seeks to provide a comprehensive understanding of the long-term consequences of COVID-19.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study.
* Male or Female, aged 18 years or above.
* Diagnosis of COVID-19 infection confirmed by detection of viral nucleic acid on reverse-transcription Polymerase Chain Reaction (RT-PCR).
* Infection should be of moderate to severe intensity (i.e, patients with clinical signs of pneumonia such as respiratory rate \> 30 breaths/min; or severe respiratory distress; or SpO2 \< 90% (on room air) and admission for \>48 hours.
* Controls: Participants with no serological evidence of previous infection, or active/previous symptoms suggestive of COVID-19, and who may or may not have comorbidities.

Exclusion Criteria:

* Contraindication to MRI e.g. pregnancy, pacemaker, ferromagnetic implant, shrapnel injury, severe claustrophobia, inability to lie flat.
* Any other significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study.
* Any signs of active COVID-19 infection on day of visit.
* Significantly impaired renal function (eGFR\<30 ml/min)

Where it's running

• University of Oxford
  Oxford, United Kingdom Recruiting

Study contacts

• Study coordinator: Betty Raman, MBBS, DPhil, FRACP
• Email: betty.raman@cardiov.ox.ac.uk
• Phone: 01865234580

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.