Investigating the link between Takotsubo Syndrome and air pollution
Official title: Takotsubo Syndrome and Air Pollution: the "Tako-Air" Study
Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT05731830 · Data updated 2026-11-12
This study is trying to see if air pollution is linked to Takotsubo Syndrome, a heart condition that can be triggered by stress or illness, to help understand how to prevent it better.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Rome) |
| Status | Recruiting |
| Started | November 15, 2022 |
| Main results expected | June 2026 |
| Study ends | November 2026 |
| Registry record updated | February 26, 2024 |
| Trial ID | NCT05731830 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have been diagnosed with Takotsubo Syndrome and have available data on their exposure to air pollutants.
✕Probably not a fit
Patients under 18 years of age or those without available data on air pollution exposure may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between air pollution and Takotsubo Syndrome (TTS), a condition characterized by acute myocardial injury often triggered by emotional stress or serious illness. The study will involve data extraction and clinical follow-up of patients diagnosed with TTS, focusing on their exposure to air pollutants. By analyzing this data, researchers hope to uncover potential risk factors and mechanisms that contribute to the severity and outcomes of TTS. The findings could enhance understanding of TTS and inform future prevention strategies.
Why it matters
Potential benefit: If successful, this study could identify air pollution as a significant risk factor for Takotsubo Syndrome, leading to improved prevention and management strategies for patients.
How similar studies have gone: While the relationship between air pollution and cardiovascular conditions has been explored, this specific investigation into Takotsubo Syndrome is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years. * Diagnosis of TTS. * Available data for short-term and/or long-term exposure to air pollutants (see below). * Written informed consent to participate. Exclusion Criteria: * Age \<18 years. * Not available data for short-term and/or long-term exposure to air pollutants.
Where it's running
-
Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome, Italy Recruiting
Study contacts
- Principal investigator: Rocco A Montone, MD, PhD — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Study coordinator: Rocco A Montone, MD, PhD
- Email: roccoantonio.montone@policlinicogemelli.it
- Phone: +39-0630154187
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.