Clinical trial Recruiting at 1 site Observational Ages 18 and up

Investigating the link between Takotsubo Syndrome and air pollution

Official title: Takotsubo Syndrome and Air Pollution: the "Tako-Air" Study

Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT05731830 · Data updated 2026-11-12

This study is trying to see if air pollution is linked to Takotsubo Syndrome, a heart condition that can be triggered by stress or illness, to help understand how to prevent it better.

More Takotsubo Cardiomyopathy trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment250 (estimated)
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS
Academic / other
Locations1 site (Rome)
StatusRecruiting
StartedNovember 15, 2022
Main results expectedJune 2026
Study endsNovember 2026
Registry record updatedFebruary 26, 2024
Trial IDNCT05731830 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who have been diagnosed with Takotsubo Syndrome and have available data on their exposure to air pollutants.

Probably not a fit

Patients under 18 years of age or those without available data on air pollution exposure may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between air pollution and Takotsubo Syndrome (TTS), a condition characterized by acute myocardial injury often triggered by emotional stress or serious illness. The study will involve data extraction and clinical follow-up of patients diagnosed with TTS, focusing on their exposure to air pollutants. By analyzing this data, researchers hope to uncover potential risk factors and mechanisms that contribute to the severity and outcomes of TTS. The findings could enhance understanding of TTS and inform future prevention strategies.

Why it matters

Potential benefit: If successful, this study could identify air pollution as a significant risk factor for Takotsubo Syndrome, leading to improved prevention and management strategies for patients.

How similar studies have gone: While the relationship between air pollution and cardiovascular conditions has been explored, this specific investigation into Takotsubo Syndrome is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥18 years.
* Diagnosis of TTS.
* Available data for short-term and/or long-term exposure to air pollutants (see below).
* Written informed consent to participate.

Exclusion Criteria:

* Age \<18 years.
* Not available data for short-term and/or long-term exposure to air pollutants.

Where it's running

  • Fondazione Policlinico Universitario A. Gemelli IRCCS
    Rome, Italy
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.