Investigating the link between gut bacteria and central serous chorioretinopathy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the potential association between gut microbiota and central serous chorioretinopathy (CSC) by comparing fecal samples from CSC patients and healthy individuals. Researchers will utilize whole-metagenome shotgun sequencing to analyze gut microbiota compositions and identify significant differences. Additionally, participants diagnosed with acute CSC will be randomly assigned to receive either Bifidobacterium supplements or a placebo for at least one month, followed by assessments of their visual acuity and gastrointestinal health. The goal is to determine if gut dysbiosis is linked to CSC and if supplementation can improve patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 to 60 years
* Diagnosis of acute central serous chorioretinopathy (CSC) (affected eye: ① FFA and ICGA showing typical CSC manifestations, ② presence of subretinal fluid (SRF) at the macular fovea, ③ disease duration ≤ 6 months)
* Best Corrected Visual Acuity (BCVA): 53 to 86 letters
* Other: No significant systemic diseases, signed informed consent, and able to commit to follow-up

Exclusion Criteria:

* Presence of significant systemic diseases
* BCVA of 20/200 or worse
* Presence of choroidal or retinal atrophy in the macular fovea of the affected eye
* Presence of choroidal neovascularization (CNV), age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV), diabetic retinopathy (DR), choroidal hemangioma, pigment epithelial detachment (PED), etc., in the affected eye
* High myopia in the affected eye

Where it's running

• 2 nd Affiliated Hospital, School of Medicine, Zhejiang University, China
  Hanzhou, Zhejiang, China Recruiting

Study contacts

• Principal investigator: Panpan Ye, doctor — 2 nd Affiliated Hospital, School of Medicine, Zhejiang University, China
• Study coordinator: Weixin Zheng, master
• Email: 22318933@zju.edu.cn
• Phone: +86 18888918935

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.