Investigating the link between estrogen levels and pain from propofol injection
Relationship Between Serum Estrogen Concentration and Propofol Injection Pain: A Prospective and Observational Study
This study is trying to see if higher estrogen levels in women affect how much pain they feel from propofol injections during anesthesia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Konya City Hospital Academic / other |
| Locations | 1 site (Konya) |
| Trial ID | NCT06929416 on ClinicalTrials.gov |
What this trial studies
This observational study examines how serum estrogen concentrations affect the incidence and severity of propofol injection pain (PIP) in female patients undergoing general anesthesia. It will include 90 female patients aged 18-45, divided into two groups: one with elevated estrogen levels due to IVF and another with normal levels undergoing elective procedures. Pain will be assessed using a standardized four-point behavioral pain scale. The findings aim to enhance understanding of hormonal influences on pain and improve patient comfort during anesthesia induction.
Who should consider this trial
Good fit: Ideal candidates are female patients aged 18-45 with ASA physical status I or II scheduled for surgery under general anesthesia.
Not a fit: Patients who may not benefit include those with ASA physical status III or IV, pregnant women, and males.
Why it matters
Potential benefit: If successful, this study could lead to improved management of injection pain during anesthesia, enhancing patient comfort.
How similar studies have performed: While the specific relationship between estrogen levels and propofol injection pain is not widely studied, hormonal influences on pain perception have been explored in other contexts, suggesting potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients aged between 18 and 45 years * American Society of Anesthesiologists (ASA) physical status I or II * Scheduled for surgery under general anesthesia * Availability of a preoperative serum estradiol (E2) level * For Group 1: Undergoing IVF procedure with supraphysiological E2 levels (\>350 pg/mL) * For Group 2: Undergoing elective surgery with normal E2 levels (15-350 pg/mL) Exclusion Criteria: * ASA physical status III or IV * Pregnant patients * Perimenopausal women * Male patients * Patients younger than 18 or older than 45 years * History of psychiatric disorders * Patients undergoing emergency surgery
Where this trial is running
Konya
- Konya City Hospital — Konya, Turkey (Recruiting)
Study contacts
- Study coordinator: Mahmut Tutar, MD
- Email: masatu42@gmail.com
- Phone: +905552723704
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.