Investigating the impact of sexual intercourse on embryo transfer outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine whether sexual intercourse the night after a frozen embryo transfer influences the implantation rates of thawed embryos. Women aged 18-41 undergoing their first four frozen embryo transfers with good quality embryos will be randomly assigned to either have intercourse or abstain for 48 hours post-transfer. Participants will complete an electronic questionnaire to confirm their sexual activity, and pregnancy outcomes will be assessed through serum tests and ultrasounds. The study seeks to clarify the effects of coitus on pregnancy success rates following embryo transfer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Women age 18-41yrs.
2. BMI (body mass index) of 18-35 kg/m².
3. Patients undergoing one of their first four frozen embryo transfers.
4. Patients transferring a good quality embryo, either a cleavage stage embryo or a day 5 blastocyst.

Exclusion Criteria:

1. Patients age above 42.
2. Moderate or poor-quality embryos.
3. Patients with hydrosalpinx or uterus malformations.
4. Patients who are not able or are not interested in having vaginal intercourse (same sex couples for example).
5. Couples undergoing preimplantation genetic diagnosis when natural cycle frozen embryo transfer is planned (as they are instructed to avoid intercourse).

Where it's running

• Sheba Medical Center
  Ramat Gan, Israel Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pentoxifylline to improve uterine lining and frozen embryo transfer outcomes

  This trial sees if giving pentoxifylline alongside standard estradiol helps women with good-quality day‑5 frozen embryos get a thicker uterine lining and better frozen embryo transfer success.

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• Comparing ICSI versus conventional IVF using frozen third‑party donor sperm

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• Triggering ovulation at smaller versus larger follicle sizes in a modified natural cycle

  This trial tests whether triggering ovulation when follicles are 13–16.9 mm works as well as triggering at 17–22 mm for people having a modified natural cycle frozen embryo transfer.

  Recruiting Vida Recoletas Sevilla · Seville, Sevilla · NCT07088952

• Effects of Corpus Luteum on Frozen Embryo Transfer Pregnancies

  This study is testing how the corpus luteum affects pregnancies from frozen embryo transfers to see if it influences things like heart health and fetal growth.

  Recruiting Phase 4 Fundacion Clinic per a la Recerca Biomédica · Barcelona, Spain · NCT06896617

• New method for embryo transfer using a semi-automated system

  This study is testing a new semi-automated system for embryo transfer to see if it can make the IVF process more precise and improve success rates for women trying to conceive.

  Recruiting at 3 sites Premium Fertility · Barcelona, Barcelona and 4 other locations · NCT06744049

• Best follicle size for triggering ovulation in women 35+ with low ovarian reserve (POSEIDON Group 4)

  This study will see if triggering ovulation when follicles measure 13–16 mm rather than waiting until >17 mm yields more mature eggs for women 35 and older with low ovarian reserve undergoing IVF.

  Recruiting Centrum Clinic IVF Center · Ankara, Ankara · NCT06433518

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.