Investigating the impact of fluid removal speed on heart strain during dialysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines how the rate of fluid removal during chronic hemodialysis affects the release of cardiac markers, specifically NT-proBNP, which is associated with heart strain. By analyzing patients who experience significant inter-dialytic weight gain, the research aims to determine if adjusting the ultrafiltration rate could improve cardiovascular outcomes. The findings may lead to updated guidelines for dialysis prescriptions to better manage fluid overload and reduce cardiac risks in patients. The study involves adult patients undergoing hemodialysis and focuses on their physiological responses during treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult HD patients with an intra-dialytic weight gain (IDWG) ≥2.5% of target weight over the long interval (3 days) prior to inclusion.
* Patients need to be able to understand the study information
* Patients need to be able to give consent.

Exclusion Criteria:

* Active systemic inflammatory state such as extensive malignancy or acute septic infection.
* Uncontrolled hyperphosphatemia decided by the local routine of the physician (due to somewhat decreased efficacy of the low flux filter to eliminate phosphate)

Where it's running

• Region Vasterbotten, Norrlands Universitetssjukhus, Dialysen
  Umeå, Sweden Recruiting

Study contacts

• Principal investigator: Bernd Stegmayr, MD, PhD — Umea University, Umea, Sweden
• Study coordinator: Bernd Stegmayr, MD, PhD
• Email: bernd.stegmayr@umu.se
• Phone: +46706264533

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.