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Clinical trial No longer in our active list Observational Ages 18 to 90

Investigating the glymphatic system using brain imaging techniques

Official title: Glymphatic Pathway in Brain Imaging: Evaluation of MRI Findings

Run by Paracelsus Medical University · NCT05035251 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is trying to see how a special contrast agent used in MRI scans moves through the brain and if it can help us understand certain brain diseases better.

Quick facts

Study typeObservational
Ages18 Years to 90 Years
SexAll
Enrollment60 (estimated)
SponsorParacelsus Medical University
Academic / other
Drugs / interventionsradiation
Locations1 site (Nuremberg, Bavaria)
Trial IDNCT05035251 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients with a clinical indication for Gadolinium-based contrast agents and no contraindications for MRI.

Probably not a fit

Patients with allergies to Gadolinium-based contrast agents or contraindications for MRI will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the pathways of Gadolinium-based contrast agents (GBCA) in various brain compartments and assess the correlation of GBCA enhancement with specific diseases. It challenges the previous assumption that GBCA does not cross the blood-brain barrier by utilizing delayed imaging techniques to reveal signal increases in cerebrospinal fluid (CSF) compartments. The study will include patients who have a clinical indication for GBCA and will involve MRI scans to detect enhancement patterns in relation to diseases and medical procedures. Written informed consent will be obtained from all participants prior to their inclusion in the study.

Why it matters

Potential benefit: If successful, this study could enhance our understanding of the glymphatic system and improve diagnostic imaging techniques for neurological conditions.

How similar studies have gone: While the approach of using GBCA in this context is relatively novel, previous studies have indicated potential for success in understanding the glymphatic system through advanced imaging techniques.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Only patients with a clinical indication for GBCA
* Written informed consent
* No allergies to GBCA

Exclusion Criteria:

* Contraindications for MRI

Where it's running

  • Institute of Radiology and Nuclear Medicine
    Nuremberg, Bavaria, Germany     Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Glymphatic System 4Paracelsus Medical University 7
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.