Investigating the glymphatic system using brain imaging techniques
Glymphatic Pathway in Brain Imaging: Evaluation of MRI Findings
Paracelsus Medical University · NCT05035251
This study is trying to see how a special contrast agent used in MRI scans moves through the brain and if it can help us understand certain brain diseases better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Paracelsus Medical University (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Nuremberg, Bavaria) |
| Trial ID | NCT05035251 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the pathways of Gadolinium-based contrast agents (GBCA) in various brain compartments and assess the correlation of GBCA enhancement with specific diseases. It challenges the previous assumption that GBCA does not cross the blood-brain barrier by utilizing delayed imaging techniques to reveal signal increases in cerebrospinal fluid (CSF) compartments. The study will include patients who have a clinical indication for GBCA and will involve MRI scans to detect enhancement patterns in relation to diseases and medical procedures. Written informed consent will be obtained from all participants prior to their inclusion in the study.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with a clinical indication for Gadolinium-based contrast agents and no contraindications for MRI.
Not a fit: Patients with allergies to Gadolinium-based contrast agents or contraindications for MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of the glymphatic system and improve diagnostic imaging techniques for neurological conditions.
How similar studies have performed: While the approach of using GBCA in this context is relatively novel, previous studies have indicated potential for success in understanding the glymphatic system through advanced imaging techniques.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Only patients with a clinical indication for GBCA * Written informed consent * No allergies to GBCA Exclusion Criteria: * Contraindications for MRI
Where this trial is running
Nuremberg, Bavaria
- Institute of Radiology and Nuclear Medicine — Nuremberg, Bavaria, Germany (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Glymphatic System, glymphatic system, imaging of blood brain barrier