Investigating the effects of proton pump inhibitors on patients with variceal bleeding and liver disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the in-hospital morbidity of patients with cirrhosis who present to the emergency department with variceal bleeding. It is a longitudinal, prospective, experimental study conducted at a single center, focusing on adult patients diagnosed with cirrhosis and experiencing variceal bleeding without shock or infection. Participants will receive intravenous omeprazole at a dosage of 40 mg as part of the intervention. The study will exclude patients with certain severe conditions to ensure a focused analysis of the target population.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Adult
* Cirrhosis
* Variceal Bleeding with only endoscopic findings consistent with portal hypertension complications
* Hypovolemic shock and Variceal bleeding

Exclusion Criteria:

* Shock of any type other than hypovolemic.
* No cirrhotic patients
* Patients that have severe Hepatic Encephalopathy at admission (West Haven 3 and 4)
* Hepatorenal syndrome
* Acute on chronic with CLIF-C \>50 points
* Septic patients
* Spontaneous Bacterial Peritonitis

Elimination Criteria

* Voluntary removal of the study
* Violation of the study protocol
* Patients in the no PBI group that need prolonged mecánica ventilación.

Where it's running

• Hospital Universitario "Jose E. González" de la Facultad de Medicina, Universidad Autónoma de Nuevo León
  Monterrey, Nuevo León, Mexico Recruiting

Study contacts

• Study coordinator: Luis A González Torres, MD
• Email: Luis37torres@gmail.com
• Phone: +5218116091332

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.