Investigating the effects of prednisolone on uterine natural killer cells in women with recurrent miscarriage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the impact of prednisolone, a glucocorticoid, on uterine natural killer (uNK) cells in women who have experienced recurrent miscarriages. Participants will receive an oral dose of 10 mg/day of prednisolone and will undergo endometrial biopsies at an outpatient clinic to assess the treatment's effects. The study seeks to clarify the inconclusive evidence surrounding prednisolone as a potential therapy for recurrent miscarriage and to understand the underlying mechanisms involved.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Women with a history of 3 or more consecutive miscarriages
2. Women younger than 40 years old

Exclusion Criteria:

1. Allergy to prednisolone
2. Women who have any uterine anomaly
3. Antiphospholipid syndrome
4. Hydrosalpinx
5. Thrombophilia
6. Abnormal thyroid function tests
7. women with diabetes,

Where it's running

• The Chinese University of Hong Kong
  Hong Kong, Hong Kong Recruiting

Study contacts

• Study coordinator: Stacey Wong, BSc
• Email: staceywong@cuhk.edu.hk
• Phone: 85235051764

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Immune cells in the uterine lining

  This project will test whether the types of immune cells in blood match the immune cells in the uterine lining in women aged 18–45 with unexplained infertility, recurrent miscarriage, or other benign gynecologic reasons who are having an endometrial biopsy.

  Recruiting Jagiellonian University · Krakow · NCT06826365

• Exploring the Role of Antibiotics in Women with Recurrent Miscarriage and Chronic Endometritis

  This study is testing if antibiotics can help women with unexplained recurrent miscarriages who also have chronic endometritis by checking for infections and seeing how well the treatment works.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT06163092

• Using prednisolone to help women with unexplained recurrent miscarriages

  This study is testing if taking prednisolone can help women who have had multiple unexplained miscarriages have a successful pregnancy.

  Recruiting Phase 4 Leiden University Medical Center · Leiden, South Holland · NCT05725512

• Immune profiling to identify biomarkers in women with repeated implantation failure or unexplained recurrent miscarriage

  This study tests immune-system blood biomarkers in women with repeated implantation failure or unexplained recurrent miscarriage to see if immune imbalances can explain their pregnancy losses.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Picardie · NCT05648136

• Mannose-binding lectin levels and repeated pregnancy or implantation failure

  This project will test whether low blood levels of mannose-binding lectin are linked to repeated pregnancy loss, repeated failed embryo transfers after IVF/ICSI/FET, or other unexplained infertility in people with three consecutive pregnancy failures.

  Recruiting Aalborg University Hospital · Aarhus · NCT05169541

• Exploring the link between decreased ovarian reserve and early miscarriages

  This study is trying to see if having a lower number of healthy eggs is linked to early miscarriages in women, to help improve fertility treatments.

  Recruiting at 3 sites ART Fertility Clinics LLC · Abu Dhabi, Abu Dhabi Emirate and 2 other locations · NCT05969574

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.