Investigating the effects of platelet-rich fibrin and vitamin D3 on root resorption
Assessment of the Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on Root Resorption: A Randomized Controlled Clinical Trial
This study is testing whether injections of platelet-rich fibrin or vitamin D3 can help reduce root resorption in patients getting their upper canine teeth moved.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 14 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Beni-Suef University Academic / other |
| Locations | 1 site (Banī Suwayf) |
| Trial ID | NCT06198322 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effects of platelet-rich fibrin (PRF) and vitamin D3 injections on root resorption in patients undergoing upper canine retraction. Participants will be randomly assigned to receive either PRF or vitamin D3 injections on one side of their mouth, while the contralateral side will serve as a control. The study will utilize cone-beam computed tomography (CBCT) to assess the outcomes. A total of 28 cases will be recruited from the Faculty of Dentistry at Beni-Suef University, with randomization and allocation concealment to ensure unbiased results.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18-40 with Class I or Class II dental malocclusion requiring upper canine retraction.
Not a fit: Patients with active periodontal disease, poor oral hygiene, or systemic conditions affecting bone metabolism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a novel approach to minimizing root resorption during orthodontic treatment.
How similar studies have performed: While the use of PRF and vitamin D3 in dental treatments has been explored, this specific comparison for root resorption is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
IInclusion criteria: 1. Age: 18- 40 years old. 2. Angle Class I or Class II dental malocclusion that required bilateral maxillary first premolar extraction and upper canine retraction as a part of the treatment plan. 3. Good to fair oral hygiene. 4. Normal probing depth. Exclusion criteria: 1. Active periodontal disease. 2. Poor oral hygiene. 3. Systemic diseases or medications that alter bone metabolism or tooth movement. 4. Craniofacial anomalies
Where this trial is running
Banī Suwayf
- Faculty of Dentistry Beni Suef University — Banī Suwayf, Egypt (Recruiting)
Study contacts
- Principal investigator: Rehab Khalil — Faculty of Dentistry Beni Suef University
- Study coordinator: Rehab Khalil
- Email: rehababdelrazek@dent.bsu.edu.eg
- Phone: 01005230669
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.