Investigating the effects of Ocrevus on cognitive fatigue in multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research examines how the disease-modifying medication Ocrevus affects cognitive fatigue in individuals with relapsing-remitting multiple sclerosis (RRMS). The study utilizes functional MRI (fMRI) to assess changes in brain activity related to cognitive fatigue during demanding tasks. Participants will include those newly prescribed Ocrevus or Copaxone, as well as healthy volunteers. The research aims to understand how cognitive fatigue evolves with treatment duration and its impact on specific brain regions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18-64.
* Relapsing remitting multiple sclerosis
* Been newly prescribed a new disease modifying medication for MS (either Ocrevus or Copaxone)
* or healthy volunteer who can speak English fluently.

Exclusion Criteria:

* History of head injury, stroke, seizures, or any other significant neurological event other than MS
* Flare up of MS symptoms within the past month.
* History of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder.
* Pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and internal hearing aids \[cochlear implants\]), permanent eyeliner, implanted delivery pumps, or shrapnel fragments.
* left handed.
* Not able to have an MRI

Where it's running

• Kessler Foundation
  West Orange, New Jersey, United States Recruiting

Study contacts

• Principal investigator: John DeLuca, PhD — Kessler Foundation
• Study coordinator: Nancy Moore, M.A.
• Email: nbmoore@kesslerfoundation.org
• Phone: 973-324-8450

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.