Investigating the effects of lidocaine infusion on pain management after surgery
Effects of Different Doses of Intravenous Lidocaine Infusion on Peri-operative Pain and Incidence of Postoperative Chronic Pain Within ERAS Protocols, a Dose Finding Study.
This study tests whether giving lidocaine through an IV during and after surgery can help reduce pain and the need for opioids in patients having open laparotomy surgeries.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Enrollment | 69 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06431165 on ClinicalTrials.gov |
What this trial studies
This study explores how different doses of intravenous lidocaine infusion can affect pain management during and after surgery, particularly focusing on its role in reducing opioid consumption and the incidence of chronic postoperative pain. It is conducted within the framework of Enhanced Recovery After Surgery (ERAS) protocols, which aim to improve recovery outcomes by minimizing the negative impacts of surgery. The study will involve patients undergoing open laparotomy surgeries and will assess the effectiveness of lidocaine in enhancing postoperative recovery and reducing complications.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 65 with ASA I and II status undergoing open laparotomy surgeries.
Not a fit: Patients who are on long-term opioid regimens or have significant hepatic or renal impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies that reduce opioid dependence and enhance recovery after surgery.
How similar studies have performed: Previous studies have shown promising results with lidocaine infusion in similar contexts, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients age between 18 and 65. * Patients with ASA I and II status. * Patients undergoing open laparotomy surgeries (including open cholecystectomies). Exclusion Criteria: * Patients unable to comprehend the informed consent. * Patients on long term pre-operative opioid regimens. * Patients with impairment in hepatic or renal functions. * Patients who are planned to receive any form of regional block for the surgery.
Where this trial is running
Cairo
- Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Alaa Magdy Ahmed Hassan, Master
- Email: loka272@yahoo.com
- Phone: 01090282616
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.