Investigating the effects of Griffonia simplicifolia on pain and sensitization in healthy volunteers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study utilizes a randomized, placebo-controlled cross-over design to evaluate the effects of Griffonia simplicifolia, which contains the serotonin precursor 5-hydroxytryptophan (5-HTP), on pain intensity and sensitization mechanisms in healthy individuals. The study aims to explore how 5-HTP influences both peripheral and central sensitization, as well as descending inhibitory pathways, using Quantitative Sensory Testing (QST). By examining these effects, the research seeks to provide insights into the analgesic efficacy of 5-HTP and its potential applications in chronic pain management.

Why it matters

Who can join: the full rules

Exclusion Criteria:

* pregnancy or breastfeeding.
* renal or hepatic insufficiency
* neurological/dermatological/cardiovascular diseases
* chronic pain and/or use of analgesics
* intake of antidepressants
* intake of MAO inhibitors
* intake of sleep medication
* intake of St. John's wort
* allergy to Griffonia simplicifolia

Where it's running

• Medical University of Graz
  Graz, Austria Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Boswellia serrata for pain sensitivity and pain modulation in healthy adults

  Researchers will test whether Boswellia serrata extract can reduce pain sensitivity and change how the body modulates pain in healthy adults.

  Recruiting Medical University of Graz · Graz, Styria · NCT07109843

• Evaluating factors related to chronic pain after hysterectomy

  This study is trying to find out what factors might lead to chronic pain after a hysterectomy in women, by looking at things like anxiety and how they feel about pain before and after the surgery.

  Recruiting KK Women's and Children's Hospital · Singapore · NCT04014829

• Cognitive Rehabilitation of Everyday Goals With GMT: How Different Ways of Delivery Work

  This study tests Goal Management Training to see if a Swedish version helps adults with acquired brain injury or chronic pain improve practical goal-directed thinking and daily functioning.

  Recruiting at 2 sites Karolinska Institutet · Luleå, Norrbotten County and 2 other locations · NCT07924774

• One-time Pain Reprocessing Therapy session for chronic pain at The Ottawa Hospital

  A single four-hour session of Pain Reprocessing Therapy is being tested to see if it can help adults with chronic pain feel better and have less pain.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT07919626

• Meaning-Based Psychotherapy for Adults with Chronic Pain

  This trial tests whether Meaning-Based Psychotherapy helps adults with chronic pain feel more purposeful, feel less depressed, and have a better quality of life compared with optimized usual care therapy.

  Recruiting Hospital Clinico Universitario San Cecilio · Granada, Granada · NCT07915440

• How chronic pain changes over time in kids with Duchenne Muscular Dystrophy

  This study is following children and teens with Duchenne Muscular Dystrophy for 6 months to see how their chronic pain changes and how it affects daily life.

  Recruiting Antalya Training and Research Hospital · Antalya, Antalya · NCT07892196

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.