Investigating the effects of galactose on metabolism during exercise
The GALAXY-1 Project: Galactose - the Ideal Carbohydrate Supplement for Exercise
This study is testing if galactose, a type of sugar, can help people with type 1 diabetes manage their blood sugar better during exercise compared to other sugars.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 8 (estimated) |
| Ages | 50 Years to 75 Years |
| Sex | All |
| Sponsor | University of Aarhus Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Aarhus N, Jutland) |
| Trial ID | NCT05986500 on ClinicalTrials.gov |
What this trial studies
This study explores the metabolic effects of galactose, a sugar that may offer benefits during exercise, particularly for individuals with type 1 diabetes. It aims to determine how galactose is utilized by skeletal muscles and the heart in response to exercise or increased insulin levels. The study employs non-invasive 18F-FDGal PET imaging to assess galactose uptake and its potential to stabilize blood sugar levels during physical activity. By comparing galactose to glucose and fructose, the research seeks to identify a safer carbohydrate source for energy production during exercise.
Who should consider this trial
Good fit: Ideal candidates are males or post-menopausal females aged 50-75 years with a BMI between 18.5 and 30 kg/m2.
Not a fit: Patients with significant heart, lung, kidney, liver, or endocrine diseases, or those unable to exercise one leg for one hour, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new nutritional strategy for individuals with diabetes to manage blood sugar levels during exercise.
How similar studies have performed: While the effects of glucose and fructose have been well-studied, the investigation of galactose as a nutritional supplement during exercise is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 50-75 years 2. Male or post-menopausal female 3. BMI 18.5-30 kg/m2 Exclusion Criteria: 1. Clinically significant heart, lung, kidney, kidney, liver, endocrine or malignant disease based on information obtained during an initial screening visit as well as blood samples 2. Blood donation within the last 3 months 3. Smoking 4. Alcohol- or substance abuse 5. Participation in other clinical trials involving ionizing radiation within the last 6 months 6. Claustrophobia 7. Not being physically able to exercise one leg for one hour
Where this trial is running
Aarhus N, Jutland
- Aarhus University Hospital — Aarhus N, Jutland, Denmark (Recruiting)
Study contacts
- Study coordinator: Thien V Luong, MD
- Email: thiluo@clin.au.dk
- Phone: +4531513750
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.