Investigating the effects of environmental pollutants on COPD and lung cancer
Mitochondrial Dysfunction and Immune Checkpoints in Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer: the Role of Environmental Pollutants
University of Campania Luigi Vanvitelli · NCT06483490
This study looks at how exposure to air pollution might affect people with COPD and lung cancer to see if it makes their conditions worse.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Campania Luigi Vanvitelli (other) |
| Locations | 1 site (Naples) |
| Trial ID | NCT06483490 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the correlation between environmental pollutants, such as particulate matter and polycyclic aromatic hydrocarbons, and the incidence of chronic obstructive pulmonary disease (COPD) and lung cancer. It will assess how these pollutants contribute to oxidative stress and inflammation, which are known to exacerbate respiratory diseases and potentially lead to cancer. The study will involve a cross-sectional analysis of patients diagnosed with suspected lung cancer, focusing on their exposure to these harmful environmental factors.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old with a clinical diagnosis of suspected lung cancer.
Not a fit: Patients with infectious diseases, interstitial lung disease, autoimmune diseases, or those on glucocorticoid therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the role of environmental pollutants in the development and progression of COPD and lung cancer, potentially leading to improved prevention strategies.
How similar studies have performed: Other studies have shown significant correlations between environmental pollutants and respiratory diseases, indicating that this approach is supported by existing epidemiological evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients of both sexes and over the age of 18 years * Clinical diagnosis of suspected lung cancer Exclusion Criteria: * Patients with infectious diseases, * Patients with interstitiopathy * Patients with autoimmune diseases * Patients with cancers not covered by the inclusion criteria * subjects on glucocorticoid therapy * subjects who cannot undergo bronchial biopsy * subjects who will not sign informed consent.
Where this trial is running
Naples
- Cardarelli Hospital — Naples, Italy (RECRUITING)
Study contacts
- Study coordinator: Bruno D'Agostino, MD, PhD
- Email: bruno.dagostino@unicampania.it
- Phone: +393472601620
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: COPD and Lung Cancer, COPD, Lung cancer, Mitochondrial dysfunction, immune checkpoints, Environmental pollution, cross-sectional, non-pharmacological