Investigating the effects of different vasopressors on brain oxygen levels during abdominal surgery
Effects of Vasopressor on Cerebral Oxygenation During General Anesthesia in Abdominal Surgery
This study is testing how different medications used to manage blood pressure during abdominal surgery affect the oxygen levels in the brain for patients under general anesthesia.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Dalian Municipal Central Hospital Academic / other |
| Locations | 1 site (Dalian, Liaoning) |
| Trial ID | NCT06334549 on ClinicalTrials.gov |
What this trial studies
This study examines how norepinephrine, phenylephrine, and ephedrine affect cerebral oxygen saturation during general anesthesia in patients undergoing abdominal surgery. It is a single-center, randomized, double-blinded, controlled trial that utilizes near-infrared spectroscopy to monitor changes in cerebral oxygen levels. The study will also measure various cardiovascular parameters such as blood pressure and cardiac output to understand the specific mechanisms of these vasopressors. The goal is to identify the most effective vasopressor for maintaining cerebral oxygenation during surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-80 undergoing elective abdominal surgery with an ASA classification of I-III.
Not a fit: Patients with severe cardiovascular disorders or unstable hemodynamics may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of cerebral oxygenation during abdominal surgeries, enhancing patient safety and outcomes.
How similar studies have performed: Other studies have explored the effects of vasopressors on cerebral oxygenation, but this specific comparison of three agents in the context of abdominal surgery is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I-III, age 18-80 years * Elective abdominal surgery * Signed informed consent Exclusion Criteria: * ASA≥IV * Preoperative unstable blood hemodynamics * Allergy to ephedrine, phenylephrine or norepinephrine * Decrease in MAP \<20% * Severe cardiovascular disorder
Where this trial is running
Dalian, Liaoning
- Dalian Municipal Central Hospital — Dalian, Liaoning, China (Recruiting)
Study contacts
- Study coordinator: Liping Han, MD, MSc
- Email: han651310@163.com
- Phone: 86-411-84412001
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.