Investigating the effects of different vasopressors on brain oxygen levels during abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines how norepinephrine, phenylephrine, and ephedrine affect cerebral oxygen saturation during general anesthesia in patients undergoing abdominal surgery. It is a single-center, randomized, double-blinded, controlled trial that utilizes near-infrared spectroscopy to monitor changes in cerebral oxygen levels. The study will also measure various cardiovascular parameters such as blood pressure and cardiac output to understand the specific mechanisms of these vasopressors. The goal is to identify the most effective vasopressor for maintaining cerebral oxygenation during surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ASA I-III, age 18-80 years
* Elective abdominal surgery
* Signed informed consent

Exclusion Criteria:

* ASA≥IV
* Preoperative unstable blood hemodynamics
* Allergy to ephedrine, phenylephrine or norepinephrine
* Decrease in MAP \<20%
* Severe cardiovascular disorder

Where it's running

• Dalian Municipal Central Hospital
  Dalian, Liaoning, China Recruiting

Study contacts

• Study coordinator: Liping Han, MD, MSc
• Email: han651310@163.com
• Phone: 86-411-84412001

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.