Investigating the effects of cold atmospheric plasma on peritoneal tumor tissue
Official title: Effects of Cold Atmospheric Plasma (CAP) on Peritoneal Tumor Tissue
Run by University Hospital, Ghent · NCT06796634 · Data updated 2026-11-12
This study is testing if a new treatment using cold plasma can help shrink tumor tissue in patients with peritoneal metastases before surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 5 (estimated) |
| Sponsor | University Hospital, Ghent Academic / other |
| Locations | 1 site (Ghent, East-Flanders) |
| Status | Recruiting |
| Started | August 21, 2024 |
| Main results expected | April 1, 2025 |
| Study ends | April 1, 2025 |
| Registry record updated | January 28, 2025 |
| Trial ID | NCT06796634 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with peritoneal metastases from cancers such as ovarian cancer, colorectal cancer, or malignant peritoneal mesothelioma who are scheduled for surgery.
✕Probably not a fit
Patients with tumors not located in the peritoneum or those who are not undergoing surgical intervention may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the effects of cold atmospheric plasma (CAP) on tumor tissue in patients with peritoneal metastases undergoing surgery. Tumor nodules will be treated with varying durations and intensities of CAP prior to surgical removal. The resected nodules will then be analyzed to assess tumor vitality and the potential impact of CAP treatment. This innovative approach seeks to provide insights into the efficacy of CAP in targeting tumor cells.
Why it matters
Potential benefit: If successful, this treatment could enhance surgical outcomes and improve survival rates for patients with peritoneal metastases.
How similar studies have gone: This approach is novel, as there are currently no existing studies examining the effects of cold atmospheric plasma on tumor tissue in patients.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Patients with peritoneal metastases undergoing surgery (CRS, debulking), irrespective of the origin. Potential cancer types include ovarian cancer, colorectal cancer, and malignant peritoneal mesothelioma * Written informed consent * Age ≥ 18 years.
Where it's running
-
UZ Ghent
Ghent, East-Flanders, Belgium Recruiting
Study contacts
- Study coordinator: Wim Ceelen, professor
- Email: wim.ceelen@ugent.be
- Phone: +3293326251
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
MT027 cell injections for advanced peritoneal tumors
We will try MT027 cell injections in adults with advanced primary or secondary peritoneal tumors to see if they are safe and show early signs of benefit.
-
Quadruplet induction plus autologous transplant followed by teclistamab maintenance for plasma cell leukemia
This phase 2 trial tests whether adding teclistamab as consolidation after autologous stem cell transplant improves overall survival for patients with plasma cell leukemia compared with the standard D-KRd consolidation.
-
Autologous stem‑cell transplant plus BCMA CAR‑T for ultra‑high‑risk multiple myeloma
This test combines an autologous stem‑cell transplant with BCMA CAR‑T therapy to see if it helps adults (18–70) with ultra‑high‑risk multiple myeloma who are eligible for transplant.
-
CT0596 CAR-T treatment for plasma cell leukemia
The study will try CT0596 CAR‑T cell therapy in adults with plasma cell leukemia to see if it is safe and can shrink the disease.
-
Observational study on immunotherapy for multiple myeloma in Norway
This study looks at how well new immunotherapy treatments for multiple myeloma work and what side effects they may cause for patients in Norway.
-
Go-slow isatuximab and dexamethasone with later lenalidomide for ultra-frail multiple myeloma patients
This trial will try a gentle, phased start of isatuximab and dexamethasone, adding lenalidomide later, for newly diagnosed, ultra-frail adults with multiple myeloma or plasma cell leukemia to help them stay on treatment and feel better.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.