Investigating the effects of cannabinoid products on motivation and focus in healthy adults

A Direct-to-Consumer, Randomized, Double-blind, Placebo-controlled, Double Cross-over Study Investigating the Effect of Specific Cannabinoid Products on Motivation, Energy Level, Focus, and Appetite in Healthy Adults

This study is testing how cannabinoid products like THCV affect motivation and focus in healthy adults over a two-week period.

Quick facts

• Study type: Observational
• Enrollment: 58 (estimated)
• Ages: 21 Years to 100 Years
• Sex: All
• Sponsor: Phylos Bioscience, Inc. (Industry-sponsored)
• Drugs / interventions: immunotherapy
• Locations: 1 site (Los Angeles, California)
• Trial ID: NCT06213064 on ClinicalTrials.gov

What this trial studies

This observational study aims to evaluate the impact of Tetrahydrocannabivarin (THCV) and other cannabinoid products on motivation, energy levels, focus, and appetite in healthy adults. Participants will report their experiences using a consumer-grade formulation of cannabinoids over a period of up to 14 days, engaging in self-reported measures and surveys after each product use session. The study is designed to gather data from a diverse group of adults who are familiar with cannabis, without a traditional physician-patient relationship. The findings will help inform future cannabis research and product development.

Who should consider this trial

Good fit: Ideal candidates are healthy adults over 21 years old who require focus in their daily activities and are familiar with cannabis use.

Not a fit: Patients with known adverse effects from cannabis or those currently taking medications for ADHD or psychotropic medications may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into how specific cannabinoid products can enhance motivation and focus in healthy adults.

How similar studies have performed: While anecdotal evidence suggests potential benefits of THCV, this study represents a novel approach to systematically investigate its effects.

Eligibility criteria

Inclusion Criteria:

1. Healthy adults age \> 21 years old
2. Work / study / play in an environment that requires focus
3. Able to read and understand English
4. Able to read, understand, and provide informed consent
5. Able to use a personal smartphone device and download Chloe by People Science
6. Able to complete study assessments over the course of up to 14 days
7. Familiar with the use of cannabis and its effects
8. Able to tolerate at least 5mg THC
9. Willingness to abstain from use of any THC containing products during study product use days
10. Willingness to abstain from use of alcohol during study product use days
11. Greater Los Angeles area residents only

Exclusion Criteria:

1. Participants who do not have a smartphone and/or internet access
2. Any known adverse effects from taking cannabis
3. Concomitant Therapies: Currently taking medication for ADHD or psychotropic medications
4. Other Illnesses or Conditions: Participants who have the following co-morbidities are excluded:

   1. History or currently undergoing product use for substance abuse disorders
   2. Currently pregnant, planning to become pregnant within the next month, or breastfeeding
   3. Allergies to formulation ingredients
   4. Current or prior psychotic disorder
   5. Immunosuppressive product uses, including organ transplant participants, active immunotherapy for cancer product use
   6. Any condition that is considered by investigator to be a contraindication to cannabis (e.g. specific drug-use interaction, unstable cardiac arrhythmia)

Where this trial is running

Los Angeles, California

• People Science, Inc. — Los Angeles, California, United States (Recruiting)

Study contacts

• Principal investigator: Noah Craft, MD — People Science, Inc.
• Study coordinator: Amy Kazaryan, MPhil

Conditions Motivation