Investigating the effects of botulinum toxin on jaw movement in people with tooth wear
The Effect on Envelope of Motion in Asymptomatic Bruxers - A Double Blinded Study
This study is testing if a botulinum toxin treatment can help improve jaw movement in people who have tooth wear from grinding their teeth.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 25 Years and up |
| Sex | All |
| Sponsor | Region Västerbotten Government |
| Locations | 1 site (Umeå, Västerbotten) |
| Trial ID | NCT05604729 on ClinicalTrials.gov |
What this trial studies
This study examines how botulinum neurotoxin affects the jaw-neck envelope of motion in individuals who experience tooth wear due to bruxism. Participants will be randomly assigned to receive either the botulinum toxin or a placebo across three sessions, spaced 12 weeks apart. The researchers will measure the jaw-neck movement before the treatment and six months after the final intervention using advanced 3D optoelectronic recording systems to assess any changes.
Who should consider this trial
Good fit: Ideal candidates are individuals with tooth wear that has progressed into the dentin.
Not a fit: Patients with temporomandibular disorders or those on medications affecting the central nervous system may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a new approach to managing tooth wear and bruxism symptoms.
How similar studies have performed: While the use of botulinum toxin for bruxism is explored in other studies, this specific approach focusing on the jaw-neck envelope of motion is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Tooth wear into dentin. Exclusion Criteria: * No temporomandibular pathology. * No drugs affecting the central nervous system. * No conditions affecting muscles or central nervous system.
Where this trial is running
Umeå, Västerbotten
- Norrlands universitetssjukhus — Umeå, Västerbotten, Sweden (Recruiting)
Study contacts
- Principal investigator: Mattias Pettersson, PhD — Umeå University
- Study coordinator: Martin Ågren, MScDS
- Email: martin.agren@umu.se
- Phone: +46907850000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.