Investigating the effects of allulose on energy expenditure and appetite
Effect of Allulose on Diet-induced Thermogenesis, Substrate Oxidation, Glycemic Response, and Satiety in Normal Weight Adults
NA · Toronto Metropolitan University · NCT06515340
This study is testing how different amounts of allulose affect energy use and hunger in healthy adults.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Toronto Metropolitan University (other) |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT06515340 on ClinicalTrials.gov |
What this trial studies
This study aims to explore how different doses of allulose affect diet-induced thermogenesis, substrate oxidation, glycemic response, and subjective appetite in healthy adults. Using a within-subject design, participants will consume varying doses of allulose on separate days, and their energy expenditure will be measured through indirect calorimetry. Blood glucose levels will be monitored continuously, and appetite will be assessed using visual analogue scales. The study will involve 10 participants, with measurements taken over a 3-hour period following treatment consumption.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 18 to 45 with a normal weight BMI between 20 and 24.9.
Not a fit: Patients with diabetes, gastrointestinal diseases, or those who are pregnant or have recently undergone major medical events may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how allulose may enhance energy expenditure and regulate appetite, potentially aiding weight management.
How similar studies have performed: While the specific effects of allulose on thermogenesis are less explored, similar studies on other sweeteners have shown promising results in metabolic regulation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants (18 - 45 years) who are considered healthy, are non-smokers, and have a body mass index (BMI) between 20 and 24.9 kg/m2 \[World Health Organization classification of normal weight BMI\]. Exclusion Criteria: * Participants who have a fasting plasma glucose \> 5.5 mmol/L indicative of impaired fasting glucose, previously diagnosed diabetes, known or uncertain pregnancy status at the screening visit, gastrointestinal disease, liver or kidney disease, have undergone a major medical or surgical event within the past 6 months, were or are on a diet, skip breakfast, smoke or have taken medication which would be a potential confounder with effects on metabolic and intake regulation. * Those unable to complete the testing protocols or are intolerant or allergic to test-day ingredients.
Where this trial is running
Toronto, Ontario
- Centre for Urban Innovation (CUI-109) — Toronto, Ontario, Canada (RECRUITING)
Study contacts
- Principal investigator: Nick Bellissimo — Toronto Metropolitan University
- Study coordinator: Nick Bellissimo
- Email: nick.bellissimo@torontomu.ca
- Phone: 4169795000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Diet Induced Thermogenesis, Adults, Allulose, Energy expenditure, Blood glucose, Appetite