Investigating the effects of a ketogenic diet on muscle growth
Effects of Ketogenic Diet on Muscle Hypertrophic Response to Resistance Exercise
This study is testing if a ketogenic diet helps healthy men who lift weights build more muscle compared to a regular diet.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Male |
| Sponsor | University of Padova Academic / other |
| Locations | 1 site (Padua) |
| Trial ID | NCT05897567 on ClinicalTrials.gov |
What this trial studies
This study examines how a ketogenic diet, characterized by low carbohydrate intake, influences muscle hypertrophy signaling following exercise in healthy trained male participants. Over a period of four weeks, subjects will undergo resistance training while adhering to either a ketogenic or a western diet. The study aims to assess changes in body composition, muscle strength, and various blood parameters as a result of the dietary intervention. The findings could provide insights into the relationship between diet and muscle development in resistance-trained individuals.
Who should consider this trial
Good fit: Ideal candidates are healthy male individuals with at least two years of resistance training experience and a BMI between 18 and 30.
Not a fit: Patients with metabolic diseases, recent steroid use, or those who have followed a ketogenic diet in the past six months may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance dietary recommendations for optimizing muscle growth and strength in resistance-trained individuals.
How similar studies have performed: While there is ongoing interest in the effects of ketogenic diets on muscle growth, this specific approach has not been extensively tested, making it a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * at least 2 years of resistance-training experience * Body mass index: more than 18 kg/m2 and less than 30 kg/m2 Exclusion Criteria: * metabolic diseases or noncommunicable diseases (cardiovascular, liver, respiratory, cancer, etc) * experience with the ketogenic diet (last six months) * acute inflammatory status * treatment with steroids in the past 3 months
Where this trial is running
Padua
- Nutex LAB — Padua, Italy (Recruiting)
Study contacts
- Principal investigator: Antonio Paoli, MD — University of Padova
- Study coordinator: Giuseppe Cerullo
- Email: giuseppe.cerullo@unipd.it
- Phone: +00393200218377
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.