Investigating the effect of H-PRF on dental implant stability
A Randomised Control Clinical Trial Investigating the Effect of Horizontal-Platelet-Rich Fibrin (H-PRF) vs Standard Placement on Implant Stability and Marginal Bone Levels in Adults
This study is testing if using a special blood product called H-PRF can make dental implants more stable for patients getting implants in their upper or lower jaw.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Dublin, Trinity College Academic / other |
| Locations | 1 site (Dublin) |
| Trial ID | NCT06453330 on ClinicalTrials.gov |
What this trial studies
This clinical trial is a randomized controlled trial that examines whether the application of Horizontal Platelet Rich Fibrin (H-PRF) can enhance the stability of dental implants compared to those placed without H-PRF. The study will recruit patients from Dublin Dental University Hospital who are scheduled for dental implants in the maxilla or mandible. Participants will undergo a preparation protocol involving the collection of their venous blood to create H-PRF, which is believed to promote bone formation and improve osseointegration. The trial aims to provide insights into the effectiveness of H-PRF in improving dental implant outcomes.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old who are scheduled for dental implants and have sufficient bone volume for placement.
Not a fit: Patients with high plaque or bleeding scores, uncontrolled systemic diseases, or those requiring bone grafting will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved stability and success rates of dental implants for patients.
How similar studies have performed: While there is limited research specifically on H-PRF, previous studies on platelet-rich fibrin have shown promising results in enhancing implant stability.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patient Level * Male or Female, 18 years old or over * Capacity to provide informed consent * Willing to comply with study appointment schedule and willing to maintain a diary of symptoms * Planned for provision of dental implant(s) at Dublin Dental University Hospital Site Level * Sufficient bone volume for implant placement without the need for bone graft/augmentation; alveolar ridge of minimum 6mm width for standard implants (implant diameter 4mm) and of minimum 7mm for wider implants (implant diameter 5mm) Exclusion Criteria: Patient Level * Plaque score \>20% * Bleeding score \>20% * Tobacco smoking * Uncontrolled systemic disease * Use of systemic medications with an expected impact on bone healing (e.g. bisphosphonates) * Pregnancy or lactation * Lack capacity to give informed consent * History of radiotherapy to the head and/or neck Site Level * Insufficient bone volume for implant placement, requiring bone graft/augmentation
Where this trial is running
Dublin
- Dublin Dental University Hospital — Dublin, Ireland (Recruiting)
Study contacts
- Principal investigator: Dr Ioannis Polyzois, Consultant — Dublin Dental University Hospital
- Study coordinator: Rawan Kahatab, BDS
- Email: kahatabr@tcd.ie
- Phone: 00353871679359
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.