Investigating the effect of diluent volume on colistin inhalation therapy for pneumonia
Official title: Effect of Diluent Volume on Colistin Inhalation Therapy for Mechanically Ventilated Respiratory Patients
Run by Fu Jen Catholic University · NCT06230614 · Data updated 2026-11-12
This study is testing whether using different amounts of saline to dilute colistin can help improve treatment outcomes for patients on ventilators with pneumonia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Fu Jen Catholic University Academic / other |
| Locations | 1 site (New Taipei City) |
| Status | Recruiting |
| Started | March 10, 2024 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | November 9, 2026 |
| Trial ID | NCT06230614 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old who are mechanically ventilated in the ICU and require inhalation colistin treatment.
✕Probably not a fit
Patients with renal failure requiring dialysis or those receiving both inhaled and intravenous colistin treatments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate how different diluent volumes affect the clinical outcomes of colistin inhalation therapy in mechanically ventilated patients with inhalation pneumonia. It will compare two groups: one receiving colistin diluted in 6 ml of saline and the other in 12 ml. The study will assess various outcomes, including ICU length of stay, hospitalization duration, respiratory support duration, and mortality rates, while also analyzing the pharmacokinetics of colistin. The goal is to identify the optimal diluent volume for improving treatment efficacy in clinical practice.
Why it matters
Potential benefit: If successful, this study could optimize colistin inhalation therapy, potentially improving recovery outcomes for critically ill patients with pneumonia.
How similar studies have gone: While the use of colistin for inhalation therapy is established, the specific investigation of diluent volume effects is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Admitted to the Intensive Care Unit. * Age greater than 18 years and using a ventilator due to acute respiratory failure. * Requires inhalation colistin treatment as determined by the disease. * Sign the written informed consent form. Exclusion Criteria: * Renal failure requiring renal dialysis. * Receiving both inhaled colistin and intravenous colistin treatments.
Where it's running
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Fu Jen Catholic University Hospital, Fu Jen Catholic University
New Taipei City, Taiwan Recruiting
Study contacts
- Principal investigator: Ke-Yun Chao, PhD — Fu Jen Catholic University Hospital
- Study coordinator: Ke-Yun Chao, PhD
- Email: C00152@mail.fjuh.fju.edu.tw
- Phone: +886-905-301-879
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.