Investigating taste responses in obese individuals before and after weight loss surgery
Taste Physiology in Obese Volunteers Before and After Bariatric Surgery
NA · University Hospital, Basel, Switzerland · NCT02902198
This study is trying to see how weight loss surgery changes the way morbidly obese people taste food and how their brains respond to it.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 16 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | University Hospital, Basel, Switzerland (other) |
| Locations | 1 site (Basel) |
| Trial ID | NCT02902198 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the neuro-anatomical responses to gastrointestinal taste stimulation in morbidly obese individuals by using functional MRI. Participants will receive intragastric administration of glucose, monosodium glutamate, chloroquine, and a placebo, followed by brain imaging before and three months after undergoing bariatric surgery. The goal is to understand how bariatric surgery affects taste perception and related brain activity in obese patients.
Who should consider this trial
Good fit: Ideal candidates are morbidly obese individuals with a BMI of at least 35 kg/m2 who are scheduled for bariatric surgery.
Not a fit: Patients with cardiovascular disease or neurologic/psychiatric disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of taste physiology in obesity and improve post-surgical outcomes for patients.
How similar studies have performed: While this approach is innovative, similar studies exploring taste physiology in obesity have shown promising results, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery * right handed Exclusion Criteria: * cardiovascular disease * neurologic/psychiatric disorders
Where this trial is running
Basel
- University Hopital Basel — Basel, Switzerland (RECRUITING)
Study contacts
- Study coordinator: Bettina Wölnerhanssen, Dr
- Email: bettina.woelnerhanssen@usb.ch
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obesity