Investigating surfactants for treating respiratory distress in preterm infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, randomized, controlled trial aims to evaluate the effectiveness of surfactants administered via a minimally invasive surfactant therapy (MIST) approach in preterm infants diagnosed with respiratory distress syndrome. Eligible infants, aged 28-35 weeks gestation and less than 48 hours old, will be randomized to receive either calfactant (Infasurf) or poractant alfa (Curosurf) while on nasal continuous positive airway pressure (NCPAP) and requiring a minimum of 30% oxygen. The study will assess the outcomes of these interventions in managing respiratory distress without the need for intubation. Parental consent will be obtained prior to randomization.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Preterm infants 28-35 6/7 weeks' gestation and less than 48 hours of age who have a clinical diagnosis of respiratory distress syndrome confirmed by a chest x-ray on nasal continuous positive airway pressure (NCPAP) and FiO2 ≥0.30

Exclusion Criteria:

* Infants will be excluded if there is a congenital anomaly or an alternative cause for respiratory distress.
* Infants who require emergent intubation will not be enrolled in the interventions.

Where it's running

• Northshore University Healthsystem
  Evanston, Illinois, United States Recruiting

Study contacts

• Study coordinator: Matthew Derrick
• Email: mderrick@northshore.org
• Phone: 18475702920

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.