Investigating STIMULAN VG for treating diabetic foot osteomyelitis

A Multi-center, Randomized, Controlled Feasibility Trial of STIMULAN VG and Debridement With an Abbreviated Course of Systemic Antibiotics to Debridement and a Full Course of Systemic Antibiotics for the Treatment of Diabetic Foot Osteomyelitis

This study is testing if a new treatment called STIMULAN VG can help people with diabetic foot osteomyelitis heal better than just using standard antibiotics after surgery.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 60 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Biocomposites Ltd (Industry-sponsored)
• Drugs / interventions: prednisone
• Locations: 10 sites (Mesa, Arizona and 9 other locations)
• Trial ID: NCT05539963 on ClinicalTrials.gov

What this trial studies

This trial evaluates the safety and effectiveness of STIMULAN VG compared to standard antibiotic treatment in patients with diabetic foot osteomyelitis. Participants will undergo surgical debridement and receive either STIMULAN VG with a short course of antibiotics or a full course of antibiotics. The study is open-label, multi-center, and randomized, aiming to gather data over approximately 55 weeks. The goal is to assess the between-group effect size of the two treatment approaches.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with a confirmed diagnosis of diabetic foot osteomyelitis requiring surgical debridement.

Not a fit: Patients without a diagnosis of diabetic foot osteomyelitis or those not requiring surgical intervention may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a safer and more effective treatment option for patients with diabetic foot osteomyelitis.

How similar studies have performed: Other studies have shown promise with similar approaches, but this specific combination of treatments is being evaluated for the first time.

Eligibility criteria

Inclusion Criteria:

Participants are eligible to be included in the trial only if all of the following criteria apply:

1. Participant must be ≥18 years of age inclusive, at the time of signing the informed consent
2. Participant has a current diagnosis and is being treated for diabetes mellitus, type 1 or type 2
3. Participant who has confirmed presence of DFO (to include all bones below the ankle including the talus and calcaneum) as evidenced by at least 3 out of 5 of the following:

   1. Positive PTB test
   2. Presence of draining sinus presumed to be from underlying bone
   3. Plain X-ray or MRI scan highly suggestive of or most compatible with osteomyelitis
   4. Ulcer present for greater than 30 days
   5. Substantially elevated serum marker for inflammation (e.g. ESR \>70 mm/hr and C-reactive protein \>14mg/L or at least 40% higher than upper limits of normal value used at the investigational site)
4. Participant who requires surgical debridement OR Participant requiring amputation and/or resection where residual osteomyelitis remains that necessitates further surgical debridement
5. All genders are eligible to participate if they are not pregnant, not breastfeeding, are not of childbearing potential or they agree to follow contraceptive guidance
6. Subject or legal authorized representative able to provide, voluntary, signed and dated informed consent prior to any study related procedures

Exclusion criteria:

Participants are excluded from the trial if any of the following criteria apply:

1. Osteomyelitis in any location other than the foot (i.e. excluding any bones located proximal to the foot)
2. Osteomyelitis of the distal phalanx (toe tip) of the great toe or lesser toes
3. Charcot foot or other deformities where the investigator believes adequate offloading is not possible
4. Severe diabetic foot infection (grade 4) in accordance to IDSA/IWGDF criteria (Appendix 6)
5. Moderate to severe reduction in renal function, defined as estimated glomerular filtration rate (eGFR) of \< 30.0 ml/min/1.73 m2 (Formula for calculating eGFR: 2021 CKD-EPI Creatinine).
6. Significant peripheral arterial disease:

   * Ankle brachial index ≤ 0.7 mm Hg OR
   * toe pressure ≤ 40 mm Hg OR
   * transcutaneous oximetry ≤ 40 mm Hg
7. Hemoglobin A1c (HbA1c) \> 12%
8. Contra-indication or inability to undergo an MRI scan
9. Malignancy that might affect trial interpretation of outcomes or the participant's ability to complete the trial
10. Participant who is severely immunocompromised or has received high dose corticosteroids (\>10 mg prednisone (or corticosteroid equivalent) for more than 14 consecutive days within the 90 days prior to informed consent)
11. Any conditions with known hypercalcemia (\> 10.3 mg/dl) or posing a significant risk for developing hypercalcemia (i.e., Hyperparathyroidism)
12. Patients with active COVID-19 will be excluded from enrollment until they are able to undergo the surgical procedure
13. Current or recent history (within last 2 years) of active substance abuse (e.g. recreational drugs, narcotics, or alcohol) that, in the judgment of the investigator, may compromise the ability of the trial participant to adhere to the trial conduct and procedures
14. Previous history of adverse incidents, allergy or contra indications (e.g. Myathesia Gravis) to any component of the investigational product, such as calcium sulfate, glycopeptide antibiotics (vancomycin), or aminoglycoside antibiotics (gentamicin)
15. Concurrent involvement in a trial of another investigational product
16. The Investigator believes trial participation may compromise safety of the participant or the results of the trial

Where this trial is running

Mesa, Arizona and 9 other locations

• Titan Clinical Research — Mesa, Arizona, United States (Recruiting)
• Axsendo Clinical Research — Phoenix, Arizona, United States (Recruiting)
• Perseverance Research Center, LLC — Scottsdale, Arizona, United States (Recruiting)
• Advanced Footcare LLC — Scottsdale, Arizona, United States (Recruiting)
• NEA Baptist Clinic — Jonesboro, Arkansas, United States (Recruiting)
• Viable Clinical Research — Henderson, Nevada, United States (Recruiting)
• Equitable Health Partners - NJ — Mountainside, New Jersey, United States (Recruiting)
• Mount Sinai West — New York, New York, United States (Recruiting)
• UNC School Medicine — Chapel Hill, North Carolina, United States (Recruiting)
• Seaside Clinical Research Institute — Wilmington, North Carolina, United States (Recruiting)

Study contacts

• Study coordinator: Keira Watts, Clinical Project Manager

Conditions Diabetic Foot Osteomyelitis; feasibility; between-group effect size; surgical debridement; systemic antibiotic