Investigating Staphylococcus aureus in the nose of patients with bacteremia
Official title: Study of the Nasal Intracellular Reservoir of Staphylococcus Aureus in Patients With S. Aureus Bacteremia
Run by Centre Hospitalier Universitaire de Saint Etienne · NCT06594250 · Data updated 2026-11-12
This study is trying to see if Staphylococcus aureus bacteria found in the nose of patients with blood infections can affect their treatment and recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 405 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Status | Recruiting |
| Started | September 2, 2024 |
| Main results expected | November 2027 |
| Study ends | November 2027 |
| Registry record updated | November 6, 2026 |
| Trial ID | NCT06594250 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients diagnosed with S. aureus bacteremia who are willing to participate and have not undergone nasal decolonization in the past year.
✕Probably not a fit
Patients currently on antibiotic therapy for more than five days or those with polymicrobial bacteremia may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the presence of an intracellular reservoir of Staphylococcus aureus in patients diagnosed with S. aureus bacteremia. The research will involve taking nasal swabs and venous samples to assess the frequency of this reservoir and its potential impact on patient prognosis. The study will also investigate whether the intracellular reservoir is linked to treatment failure and the role of autophagy in the survival of the bacteria. By understanding these mechanisms, the study seeks to shed light on the complexities of S. aureus infections.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients suffering from S. aureus bacteremia.
How similar studies have gone: While the concept of intracellular reservoirs in bacteria is being explored, this specific investigation into S. aureus bacteremia is novel and has not been extensively studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Bacteremia * Patient affiliated or entitled to a social security plan * Patient who has signed a consent form to participate in the study. Exclusion Criteria: * Antibiotic therapy in place for more than 5 days at the time of inclusion * Nasal decolonization of S. aureus within 12 months * Pregnant or breast-feeding women * Patients under guardianship * Polymicrobial bacteremia including S. aureus
Where it's running
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Centre Hospitalier Universitaire de St Etienne
Saint-Etienne, France Recruiting
Study contacts
- Principal investigator: Elisabeth BOTELHO-NEVERS, MD-PhD — Centre Hospitalier Universitaire de Saint Etienne
- Study coordinator: Elisabeth BOTELHO-NEVERS, MD-PhD
- Email: elisabeth.botelho-nevers@chu-st-etienne.fr
- Phone: (0)477120764
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.