Investigating Staphylococcus aureus in the nose of patients with bacteremia
Study of the Nasal Intracellular Reservoir of Staphylococcus Aureus in Patients With S. Aureus Bacteremia
This study is trying to see if Staphylococcus aureus bacteria found in the nose of patients with blood infections can affect their treatment and recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 405 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Trial ID | NCT06594250 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the presence of an intracellular reservoir of Staphylococcus aureus in patients diagnosed with S. aureus bacteremia. The research will involve taking nasal swabs and venous samples to assess the frequency of this reservoir and its potential impact on patient prognosis. The study will also investigate whether the intracellular reservoir is linked to treatment failure and the role of autophagy in the survival of the bacteria. By understanding these mechanisms, the study seeks to shed light on the complexities of S. aureus infections.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with S. aureus bacteremia who are willing to participate and have not undergone nasal decolonization in the past year.
Not a fit: Patients currently on antibiotic therapy for more than five days or those with polymicrobial bacteremia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients suffering from S. aureus bacteremia.
How similar studies have performed: While the concept of intracellular reservoirs in bacteria is being explored, this specific investigation into S. aureus bacteremia is novel and has not been extensively studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Bacteremia * Patient affiliated or entitled to a social security plan * Patient who has signed a consent form to participate in the study. Exclusion Criteria: * Antibiotic therapy in place for more than 5 days at the time of inclusion * Nasal decolonization of S. aureus within 12 months * Pregnant or breast-feeding women * Patients under guardianship * Polymicrobial bacteremia including S. aureus
Where this trial is running
Saint-Etienne
- Centre Hospitalier Universitaire de St Etienne — Saint-Etienne, France (Recruiting)
Study contacts
- Principal investigator: Elisabeth BOTELHO-NEVERS, MD-PhD — Centre Hospitalier Universitaire de Saint Etienne
- Study coordinator: Elisabeth BOTELHO-NEVERS, MD-PhD
- Email: elisabeth.botelho-nevers@chu-st-etienne.fr
- Phone: (0)477120764
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.