Investigating specific proteins associated with asthma

The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma: A Case-control Study

This study looks at specific proteins in people with asthma to see how they relate to asthma symptoms and compare them with healthy individuals.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 14 Years to 75 Years
• Sex: All
• Sponsor: Shanghai University of Traditional Chinese Medicine (Academic / other)
• Locations: 2 sites (Changsha, Hunan and 1 other locations)
• Trial ID: NCT05496582 on ClinicalTrials.gov

What this trial studies

This observational study aims to explore the changes in gene expression of transgelin-2, metallothionein-2, and ezrin in individuals diagnosed with asthma. The researchers will assess the correlation of these proteins with established asthma diagnostic markers, such as pulmonary function tests and inflammatory markers. By comparing asthmatic patients with healthy volunteers, the study seeks to enhance understanding of the molecular mechanisms underlying asthma. No interventions will be administered, as the focus is on observational data collection.

Who should consider this trial

Good fit: Ideal candidates include males and females aged 14-75 with a confirmed diagnosis of bronchial asthma.

Not a fit: Patients with chronic obstructive pulmonary disease or other severe primary diseases may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic markers and therapeutic targets for asthma management.

How similar studies have performed: Previous studies have identified similar associations in animal models, but this investigation in humans is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Males or females, aged 14-75 years;
2. Patients with a definite diagnosis of bronchial asthma;
3. The diagnosis of asthma according to the Global Initiative for Asthma (GINA), with positive bronchodilator responsiveness (reversibility) test;
4. Healthy volunteers without respiratory symptoms such as cough, wheezing, chest tightness or dyspnea;
5. Agree with all procedures in this trial by signing a written informed consent form.

Exclusion Criteria:

1. Patients with chronic obstructive pulmonary disease or other airway disease;
2. Complicated with other severe primary diseases (including hypertension, cancer, hyperthyroidism, bronchiectasia, cardiac insufficiency) and conditions that would prevent participation in the trial or put the participant at risk;
3. Women who are known to be pregnant or breastfeeding;
4. Not willing to participate;
5. Psychiatric history and neurological disorders can not work normally;
6. Other conditions that the researcher considers inappropriate to participate in this study.

Where this trial is running

Changsha, Hunan and 1 other locations

• Xiangya Hospital, Central South University — Changsha, Hunan, China (Recruiting)
• Yueyang Hospital, Shanghai University of Traditional Chinese Medicine — Shanghai, Shanghai Municipality, China (Not_yet_recruiting)

Study contacts

• Study coordinator: Lei-Miao Yin, MD

Conditions Asthma