Investigating senescent cells in women with thin endometrial lining
Official title: Is Thin Endometrial Lining Associated With Senescent Endometrial Cells
Run by Trio Fertility · NCT06450301 · Data updated 2026-11-12
This study is testing whether certain aging cells in the uterus are linked to thin uterine lining in women who have used birth control pills for a long time, to help understand fertility issues.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 39 Years |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | Trio Fertility Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | September 11, 2024 |
| Main results expected | September 2027 |
| Study ends | September 2027 |
| Registry record updated | November 3, 2026 |
| Trial ID | NCT06450301 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18-39 with thin endometrial lining after oral contraceptive use and those diagnosed with Asherman's syndrome.
✕Probably not a fit
Patients with systemic diseases, coagulopathies, or those currently using hormonal contraception will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between senescent endometrial cells and thin endometrial lining in women who have used oral contraceptives long-term. Participants will undergo gynecologic ultrasound to assess endometrial thickness and an endometrial biopsy to evaluate the presence of senescent cells. The study seeks to determine if these senescent cells contribute to the failure of the endometrium to respond to estrogen, which is crucial for fertility. The findings could provide insights into the underlying mechanisms affecting women with Asherman's syndrome and thin endometrial lining.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment options for women experiencing infertility due to thin endometrial lining.
How similar studies have gone: While the specific focus on senescent cells in thin endometrial lining is novel, related studies have explored endometrial health and cell senescence, indicating potential for meaningful findings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-39 * BMI - up to 35 * Thin endometrium after OCP use * Asherman's syndrome * Women already undergoing endometrial biopsy for infertility testing (eg. EMMA testing) * Women with archived endometrial biopsy samples Exclusion Criteria: * Women with systemic disease (Rheumatic disease, DM) * Women with coagulopathies * Women with active pelvic inflammatory process * Uterine anomalies * Pregnant women * Any hormonal contraception use or IUD
Where it's running
-
Trio Fertility
Toronto, Ontario, Canada Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.