Investigating sedation methods for stroke treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine the feasibility of using procedural sedation compared to general anesthesia for patients undergoing endovascular treatment for vertebrobasilar stroke. The study will involve a prospective randomized design with a parallel-group approach, where patients will be assigned to either sedation or general anesthesia during their procedure. The goal is to gather high-level evidence on the impact of anesthetic modality on functional outcomes in this specific patient population, which has been under-researched compared to anterior circulation strokes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Decision for thrombectomy according to local protocol for acute recanalizing stroke treatment
2. Age 18 years or older, either sex
3. National Institutes of Health Stroke Scale (NIHSS) ≥ 4
4. Acute ischemic stroke in the posterior circulation with isolated or combined occlusion of vertebral artery (VA) and basilar artery (BA)
5. Informed consent by the patient him-/herself or his/her legal representative obtainable within 72 h of treatment (deferred consenting procedure)

Exclusion Criteria:

1. Intracerebral hemorrhage
2. Coma on admission (Glasgow Coma Scale ≤ 8)
3. Severe respiratory instability, loss of airway protective reflexes or vomiting on admission, where primary intubation and general anesthesia is deemed necessary
4. Intubated state before randomization
5. Severe hemodynamic instability (e.g. due to decompensated cardiac insufficiency)

Where it's running

• Department of Neurology, University Hospital Heidelberg
  Heidelberg, Baden-Wurttemberg, Germany Recruiting

Study contacts

• Principal investigator: Silvia Schönenberger, MD — University Hospital Heidelberg
• Study coordinator: Min Chen, MD
• Email: min.chen@med.uni-heidelberg.de
• Phone: 0049/6221/7504

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Are pediatric emergency plans in German children's hospitals ready for disasters?

  This study tests whether children's hospitals in Germany have child-specific emergency and response plans and aims to offer recommendations to improve resilience.

  Recruiting University Hospital Heidelberg · Heidelberg · NCT07766941

• Gender and Borderline Personality Disorder: a look at relationships and self-view

  This study tests how gender identities relate to relationship experiences and self-perception in people with borderline personality disorder.

  Recruiting University Hospital Heidelberg · Heidelberg · NCT07639957

• Mentalization-based prevention program to boost well-being for 8–11 year olds and families

  A multi-country program tests whether a family-focused, mentalization-based approach can improve well-being and mental health in primary-school children and their parents.

  Recruiting at 4 sites University Hospital Heidelberg · Heidelberg and 3 other locations · NCT07494929

• Probiotics with or without vitamin B12 added to non-surgical treatment for advanced periodontitis

  This study will see if taking a probiotic lozenge alone or together with vitamin B12 during non-surgical periodontal treatment changes the oral microbiome and helps adults with Stage III or IV periodontitis.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT07443410

• Same-day ambulatory stroke unit care for older adults with minor stroke or TIA

  This trial will try whether same-day ambulatory stroke unit care works as well as inpatient stroke unit care for people aged 60 and older with minor ischemic stroke, transient ischemic attack, or retinal ischemia.

  Recruiting University Hospital Heidelberg · Heidelberg · NCT07420374

• Duchenne/Becker Muscular Dystrophy Registry for patients and carriers

  This registry tests whether patients with Duchenne or Becker muscular dystrophy, or symptomatic female carriers, can be enrolled and followed across specialist centers to improve data sharing and care.

  Recruiting at 19 sites University Hospital Heidelberg · Graz and 29 other locations · NCT07402122

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.