Investigating respiratory microbiota and immune response in patients with CVID
Alteration of Respiratory Microbiota and Local Immune Response in Common Variable Immunodeficiency
This study looks at how the immune system and germs in the lungs interact in people with common variable immunodeficiency (CVID) to better understand their respiratory problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Boston University Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT06173128 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on common variable immunodeficiency (CVID), a primary immunodeficiency that often leads to respiratory complications. The research aims to explore how antibody deficiencies in CVID affect the respiratory microbiota and the interactions between microbes and host cells. By directly sampling the respiratory tract, the study will utilize advanced bioinformatics to analyze these complex interactions. The goal is to better understand the pulmonary biology in CVID patients and the underlying mechanisms driving respiratory diseases.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with primary antibody deficiency, specifically CVID.
Not a fit: Patients who are pregnant or have uncontrolled asthma or COPD may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of respiratory complications in CVID patients.
How similar studies have performed: While the specific approach of this study may be novel, similar studies investigating microbiota interactions in other immunodeficiencies have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with primary antibody deficiency diagnosed by their treating physician * Controls will not have a diagnosis of immunodeficiency of any sort * Male and female patients will be enrolled evenly Exclusion Criteria: * Patients who self identify as pregnant * Patients with asthma or chronic obstructive pulmonary disease (COPD) that are not well controlled clinically
Where this trial is running
Boston, Massachusetts
- Boston Medical Center — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Paul J Maglione, MD PhD — Boston University Chobanian & Avedisian School of Medicine, Pulmonary Center
- Study coordinator: Paul J Maglione, MD PhD
- Email: pmaglion@bu.edu
- Phone: 617 358 0913
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.