Investigating recurrent yeast infections in women
Prospective Studies of Vaginal Yeast and Microbiome Related to Vulvovaginal Candidiasis in Canadian Females
EARLY_PHASE1 · University of Manitoba · NCT04930107
This study is testing how well different treatments work for women who keep getting yeast infections to understand why some women have recurring issues despite treatment.
Quick facts
| Phase | EARLY_PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 105 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Female |
| Sponsor | University of Manitoba (other) |
| Locations | 1 site (Winnipeg, Manitoba) |
| Trial ID | NCT04930107 on ClinicalTrials.gov |
What this trial studies
This study focuses on vulvovaginal candidiasis, a common yeast infection affecting many women. It aims to explore the relationship between Candida fungi, the vaginal microbiome, and the immune system to better understand recurrent infections. Participants will receive treatments including Fluconazole and Boric Acid to assess their effectiveness. The study seeks to clarify why some women experience recurrent infections despite treatment.
Who should consider this trial
Good fit: Ideal candidates are females aged 18 to 50 who experience recurrent vulvovaginal candidiasis.
Not a fit: Patients who are currently pregnant, trying to get pregnant, have had a hysterectomy, or have bacterial vaginosis will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for women suffering from recurrent yeast infections.
How similar studies have performed: While there is ongoing research in this area, the specific approach of linking the microbiome and immune response to recurrent infections is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female * Between ages of 18 and 50 years. Exclusion Criteria: * Currently pregnant * Trying to get pregnant * Have had a hysterectomy * BV infection
Where this trial is running
Winnipeg, Manitoba
- Health Science Centre (HSC) — Winnipeg, Manitoba, Canada (RECRUITING)
Study contacts
- Principal investigator: Aleeza Gerstein, PhD — University of Manitoba
- Study coordinator: Vanessa Poliquin, MD
- Email: vpoliquin@hsc.mb.ca
- Phone: 204-787-4796
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Candidiasis, Vulvovaginal