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Investigating reconstruction methods after pelvic cancer surgery

REMACS - Understanding the Impact of Perineal Reconstruction After Extended MArgin Cancer Surgery on Longer-term Quality of Life, Morbidity and Health Economic Outcomes - a Prospective Longitudinal Cohort Study

Observational University Hospital Southampton NHS Foundation Trust · NCT05219058

This study looks at different ways to rebuild the body after pelvic cancer surgery to see how they affect recovery, quality of life, and healthcare costs for patients.

Quick facts

Study typeObservational
Enrollment236 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity Hospital Southampton NHS Foundation Trust Academic / other
Drugs / interventionschemotherapy
Locations18 sites (Southampton, Hampshire and 17 other locations)
Trial IDNCT05219058 on ClinicalTrials.gov

What this trial studies

This observational study focuses on patients undergoing pelvic cancer surgeries, specifically pelvic exenteration and abdominoperineal excision. It aims to collect and analyze data on complication rates, quality of life, and healthcare resource utilization associated with various reconstruction techniques. The study includes maintaining a comprehensive database, conducting a national collaborative study, and performing qualitative interviews to gather patient experiences. By evaluating these factors, the research seeks to enhance decision-making for patients and healthcare providers regarding reconstruction options.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 or older who have undergone pelvic exenteration or abdominoperineal excision at participating hospitals.

Not a fit: Patients who are unfit for surgery, decline the procedure, or are unable to provide informed consent may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved surgical outcomes and quality of life for patients undergoing complex pelvic cancer surgeries.

How similar studies have performed: While similar studies have explored surgical outcomes in pelvic cancer, this specific approach to evaluating reconstruction techniques is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Male and female patients aged 18 or older
* Patients that have undergone pelvic exenteration or abdominoperineal excision at participating sites, at any time, that have complete data (work package 1 - Colorectal Surgery Database)
* Patients undergoing pelvic exenteration or abdominoperineal excision at participating sites (work package 2 - prospective study)
* Patients that have already had pelvic exenteration or abdominoperineal resection that can speak English (work package 3 - mixed-methods study)

Exclusion Criteria:

* Patients eligible for, but that are unfit, decline or are not offered abdominoperineal excision or pelvic exenteration surgery
* Patients that undergo surgery by an intersphincteric abdominoperineal resection approach
* Patients that are unable to complete the questionnaire over the telephone or online with a researcher
* Patients unable or unwilling to provide informed consent
* Patients that are prisoners in the custody of HM Prison Service or who are offenders supervised by the probation service

Where this trial is running

Southampton, Hampshire and 17 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Surgery--ComplicationsPelvic CancerAbdominal CancerQuality of Life
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.